Entity Details

Name PPP2CA_Thr423
ID Q13153
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PDPK1PAK1Thr423PEQSKRStMVGTPYWphosphorylation
up-regulates activity		10995762SIGNOR-250267
PPP2CBPAK1Thr423PEQSKRStMVGTPYWdephosphorylation
down-regulates activity		18586681SIGNOR-248600
PPM1APAK1Thr423PEQSKRStMVGTPYWdephosphorylation
down-regulates activity		18586681SIGNOR-248491
PPP2CAPAK1Thr423PEQSKRStMVGTPYWdephosphorylation
down-regulates activity		18586681SIGNOR-248643
PPM1EPAK1Thr423PEQSKRStMVGTPYWdephosphorylation
down-regulates activity		11864573SIGNOR-248761
PPM1FPAK1Thr423PEQSKRStMVGTPYWdephosphorylation
down-regulates activity		11864573SIGNOR-248531
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PDPK1phosphorylation
up-regulates
→
PAK1
PThr423		phosphorylation
up-regulates
→		PAK110995762SIGNOR-250267
PPP2CBdephosphorylation
down-regulates
⊣
PAK1
PThr423		dephosphorylation
up-regulates
→		PAK118586681SIGNOR-248600
PPM1Adephosphorylation
down-regulates
⊣
PAK1
PThr423		dephosphorylation
up-regulates
→		PAK118586681SIGNOR-248491
PPP2CAdephosphorylation
down-regulates
⊣
PAK1
PThr423		dephosphorylation
up-regulates
→		PAK118586681SIGNOR-248643
PPM1Edephosphorylation
down-regulates
⊣
PAK1
PThr423		dephosphorylation
up-regulates
→		PAK111864573SIGNOR-248761
PPM1Fdephosphorylation
down-regulates
⊣
PAK1
PThr423		dephosphorylation
up-regulates
→		PAK111864573SIGNOR-248531
Regulator Mechanism/Effect Target SIGNOR-ID
PDPK1phosphorylation
→
up-regulates activity 		PAK1SIGNOR-250267
PPP2CBdephosphorylation
→
down-regulates activity 		PAK1SIGNOR-248600
PPM1Adephosphorylation
→
down-regulates activity 		PAK1SIGNOR-248491
PPP2CAdephosphorylation
→
down-regulates activity 		PAK1SIGNOR-248643
PPM1Edephosphorylation
→
down-regulates activity 		PAK1SIGNOR-248761
PPM1Fdephosphorylation
→
down-regulates activity 		PAK1SIGNOR-248531