Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAP2K5	MAPK7	Thr219	AEHQYFMtEYVATRW	phosphorylation up-regulates activity	20667468	SIGNOR-259824
MAP2K5	MAPK7	–		phosphorylation up-regulates	11782488	SIGNOR-113770
CDK5	MAPK7	Thr733 View in OncoXplorer	LPPVFSGtPKGSGAG	phosphorylation up-regulates activity	27735944	SIGNOR-279364
MAPK7	MAPK7	Ser803 View in OncoXplorer	QREIQMDsPMLLADL	phosphorylation up-regulates activity	20667468	SIGNOR-259826
PTPRR	MAPK7	Tyr221 View in OncoXplorer	HQYFMTEyVATRWYR	dephosphorylation down-regulates activity	12042304	SIGNOR-248721
BRAF	MAPK7	Tyr221 View in OncoXplorer	HQYFMTEyVATRWYR	phosphorylation up-regulates quantity	29483645	SIGNOR-278353
MAPK7	MAPK7	Thr733 View in OncoXplorer	LPPVFSGtPKGSGAG	phosphorylation up-regulates activity	20667468	SIGNOR-259822
DUSP6	MAPK7	–		dephosphorylation down-regulates activity	18280112	SIGNOR-277007
MAPK7	MAPK7	Ser731 View in OncoXplorer	DPLPPVFsGTPKGSG	phosphorylation up-regulates activity	20667468	SIGNOR-259821
PRKCZ	MAPK7	–		phosphorylation down-regulates activity	20538799	SIGNOR-280090
MAPK7	MAPK7	Ser567 View in OncoXplorer	VLSDNDRsLLERWTR	phosphorylation up-regulates activity	20667468	SIGNOR-259823
BRAF	MAPK7	Thr219	AEHQYFMtEYVATRW	phosphorylation up-regulates quantity	29483645	SIGNOR-278352
MAP2K5	MAPK7	–		phosphorylation up-regulates activity	23612709	SIGNOR-255453
MAP2K5	MAPK7	–		phosphorylation up-regulates	12912994	SIGNOR-104631
MAP2K5	MAPK7	Tyr221 View in OncoXplorer	HQYFMTEyVATRWYR	phosphorylation up-regulates activity	20667468	SIGNOR-259825

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAP2K5	phosphorylation up-regulates →	MAPK7 PThr219	phosphorylation up-regulates →	MAPK7	20667468	SIGNOR-259824
CDK5	phosphorylation up-regulates →	MAPK7 PThr733	phosphorylation up-regulates →	MAPK7	27735944	SIGNOR-279364
MAPK7	phosphorylation up-regulates →	MAPK7 PSer803	phosphorylation up-regulates →	MAPK7	20667468	SIGNOR-259826
PTPRR	dephosphorylation down-regulates ⊣	MAPK7 PTyr221	dephosphorylation up-regulates →	MAPK7	12042304	SIGNOR-248721
BRAF	phosphorylation up-regulates →	MAPK7 PTyr221	phosphorylation up-regulates →	MAPK7	29483645	SIGNOR-278353
MAPK7	phosphorylation up-regulates →	MAPK7 PThr733	phosphorylation up-regulates →	MAPK7	20667468	SIGNOR-259822
MAPK7	phosphorylation up-regulates →	MAPK7 PSer731	phosphorylation up-regulates →	MAPK7	20667468	SIGNOR-259821
MAPK7	phosphorylation up-regulates →	MAPK7 PSer567	phosphorylation up-regulates →	MAPK7	20667468	SIGNOR-259823
BRAF	phosphorylation up-regulates →	MAPK7 PThr219	phosphorylation up-regulates →	MAPK7	29483645	SIGNOR-278352
MAP2K5	phosphorylation up-regulates →	MAPK7 PTyr221	phosphorylation up-regulates →	MAPK7	20667468	SIGNOR-259825

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAP2K5	phosphorylation → up-regulates activity	MAPK7	SIGNOR-259824
MAP2K5	phosphorylation → up-regulates	MAPK7	SIGNOR-113770
CDK5	phosphorylation → up-regulates activity	MAPK7	SIGNOR-279364
MAPK7	phosphorylation → up-regulates activity	MAPK7	SIGNOR-259826
PTPRR	dephosphorylation → down-regulates activity	MAPK7	SIGNOR-248721
BRAF	phosphorylation → up-regulates quantity	MAPK7	SIGNOR-278353
MAPK7	phosphorylation → up-regulates activity	MAPK7	SIGNOR-259822
DUSP6	dephosphorylation → down-regulates activity	MAPK7	SIGNOR-277007
MAPK7	phosphorylation → up-regulates activity	MAPK7	SIGNOR-259821
PRKCZ	phosphorylation → down-regulates activity	MAPK7	SIGNOR-280090
MAPK7	phosphorylation → up-regulates activity	MAPK7	SIGNOR-259823
BRAF	phosphorylation → up-regulates quantity	MAPK7	SIGNOR-278352
MAP2K5	phosphorylation → up-regulates activity	MAPK7	SIGNOR-255453
MAP2K5	phosphorylation → up-regulates	MAPK7	SIGNOR-104631
MAP2K5	phosphorylation → up-regulates activity	MAPK7	SIGNOR-259825