| + |
MAPK7 | up-regulates 
phosphorylation
|
MAP2K5 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99127 |
Ser129 |
VNTRAGPsQHSSPAV |
Homo sapiens |
|
| pmid |
sentence |
| 12628002 |
Phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (erk5) by mitogen-activated protein kinase kinase 5 (mkk5)activated erk5 also phosphorylated mitogen-activated protein kinase kinase 5 (mkk5) extensively at ser(129), ser(137), ser(142) and ser(149) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99131 |
Ser137 |
QHSSPAVsDSLPSNS |
Homo sapiens |
|
| pmid |
sentence |
| 12628002 |
Phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (erk5) by mitogen-activated protein kinase kinase 5 (mkk5)activated erk5 also phosphorylated mitogen-activated protein kinase kinase 5 (mkk5) extensively at ser(129), ser(137), ser(142) and ser(149) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99135 |
Ser142 |
AVSDSLPsNSLKKSS |
Homo sapiens |
|
| pmid |
sentence |
| 12628002 |
Phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (erk5) by mitogen-activated protein kinase kinase 5 (mkk5)activated erk5 also phosphorylated mitogen-activated protein kinase kinase 5 (mkk5) extensively at ser(129), ser(137), ser(142) and ser(149) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99139 |
Ser149 |
SNSLKKSsAELKKIL |
Homo sapiens |
|
| pmid |
sentence |
| 12628002 |
Phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (erk5) by mitogen-activated protein kinase kinase 5 (mkk5)activated erk5 also phosphorylated mitogen-activated protein kinase kinase 5 (mkk5) extensively at ser(129), ser(137), ser(142) and ser(149) |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
MAPK7 | up-regulates
phosphorylation
|
MEF2D |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236041 |
Ser180 |
LTDPRLLsPQQPALQ |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10849446 |
Here, we demonstrate that, in addition to mef2c, bmk1 phosphorylates and activates mef2a and mef2d but not mef2b. the sites phosphorylated by activated bmk1 were mapped to ser-355, thr-312, and thr-319 of mef2a and ser-179 of mef2d both in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK7 | down-regulates activity 
phosphorylation
|
GJA1 |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250115 |
Ser255 |
HATSGALsPAKDCGS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12637502 |
Activated BMK1 selectively phosphorylates Cx43 on Ser-255 in vitro and in vivo. These data demonstrate that BMK1 kinase activity alone is both a necessary and sufficient component in the mediation of EGF-induced Cx43 Ser-255 phosphorylation and subsequent inhibition of GJC. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK7 | up-regulates
phosphorylation
|
MEF2A |
0.709 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236587 |
Ser355 |
SALQGFNsPGMLSLG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10849446 |
We have previously shown that bmk1 regulates c-jun gene expression through direct phosphorylation and activation of transcription factor mef2c.Here, we demonstrate that, in addition to mef2c, bmk1 phosphorylates and activates mef2a and mef2d but not mef2b.The sites phosphorylated by activated bmk1 were mapped to ser-355, thr-312, and thr-319 of mef2a and ser-179 of mef2d both in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236583 |
Thr312 |
QATQPLAtPVVSVTT |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10849446 |
We have previously shown that bmk1 regulates c-jun gene expression through direct phosphorylation and activation of transcription factor mef2c.Here, we demonstrate that, in addition to mef2c, bmk1 phosphorylates and activates mef2a and mef2d but not mef2b.The sites phosphorylated by activated bmk1 were mapped to ser-355, thr-312, and thr-319 of mef2a and ser-179 of mef2d both in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236579 |
Thr319 |
TPVVSVTtPSLPPQG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10849446 |
We have previously shown that bmk1 regulates c-jun gene expression through direct phosphorylation and activation of transcription factor mef2c.Here, we demonstrate that, in addition to mef2c, bmk1 phosphorylates and activates mef2a and mef2d but not mef2b.The sites phosphorylated by activated bmk1 were mapped to ser-355, thr-312, and thr-319 of mef2a and ser-179 of mef2d both in vitro and in vivo. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAPK7 | up-regulates
phosphorylation
|
MEF2C |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53545 |
Ser387 |
LSLPSTQsLNIKSEP |
Homo sapiens |
|
| pmid |
sentence |
| 9384584 |
Bmk1 dramatically enhances the transactivation activity of mef2c by phosphorylating a serine residue at amino acid position 387 in this transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK7 | up-regulates activity
phosphorylation
|
MAPK7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259823 |
Ser567 |
VLSDNDRsLLERWTR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20667468 |
Activated ERK5 undergoes autophosphorylation on its C-terminal half, necessary for maximal activation of ERK5 transcriptional activation. The Ser731 and Thr733 sites were previously shown to be ERK5 autophosphorylation sites in vitro and also in ERK5-overexpressing cells.Our data coincide with a recent study examining whole protein phosphorylation in HeLa cells arrested in G1 and mitotic phases [37] reported that Ser731 and Thr733, as well as Ser720, are phosphorylated in ERK5 during mitosis. We also identified two unreported ERK5 phosphorylation sites, Ser567 and Ser803. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259821 |
Ser731 |
DPLPPVFsGTPKGSG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20667468 |
Activated ERK5 undergoes autophosphorylation on its C-terminal half, necessary for maximal activation of ERK5 transcriptional activation. The Ser731 and Thr733 sites were previously shown to be ERK5 autophosphorylation sites in vitro and also in ERK5-overexpressing cells.Our data coincide with a recent study examining whole protein phosphorylation in HeLa cells arrested in G1 and mitotic phases [37] reported that Ser731 and Thr733, as well as Ser720, are phosphorylated in ERK5 during mitosis. We also identified two unreported ERK5 phosphorylation sites, Ser567 and Ser803. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259826 |
Ser803 |
QREIQMDsPMLLADL |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20667468 |
Activated ERK5 undergoes autophosphorylation on its C-terminal half, necessary for maximal activation of ERK5 transcriptional activation. The Ser731 and Thr733 sites were previously shown to be ERK5 autophosphorylation sites in vitro and also in ERK5-overexpressing cells.Our data coincide with a recent study examining whole protein phosphorylation in HeLa cells arrested in G1 and mitotic phases [37] reported that Ser731 and Thr733, as well as Ser720, are phosphorylated in ERK5 during mitosis. We also identified two unreported ERK5 phosphorylation sites, Ser567 and Ser803. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259822 |
Thr733 |
LPPVFSGtPKGSGAG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20667468 |
Activated ERK5 undergoes autophosphorylation on its C-terminal half, necessary for maximal activation of ERK5 transcriptional activation. The Ser731 and Thr733 sites were previously shown to be ERK5 autophosphorylation sites in vitro and also in ERK5-overexpressing cells.Our data coincide with a recent study examining whole protein phosphorylation in HeLa cells arrested in G1 and mitotic phases [37] reported that Ser731 and Thr733, as well as Ser720, are phosphorylated in ERK5 during mitosis. We also identified two unreported ERK5 phosphorylation sites, Ser567 and Ser803. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
MAPK7 | up-regulates
phosphorylation
|
SGK1 |
0.389 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105728 |
Ser78 |
ANPSPPPsPSQQINL |
Homo sapiens |
|
| pmid |
sentence |
| 11254654 |
Bmk1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinasebmk1 activates sgk by phosphorylation at serine 78. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K5 | up-regulates activity
phosphorylation
|
MAPK7 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259824 |
Thr219 |
AEHQYFMtEYVATRW |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20667468 |
ERK5 is a member of the mitogen-activated protein kinase (MAPK) family that, after stimulation, is activated selectively by dual phosphorylation in the TEY motif by MAPK kinase 5 (MEK5). ERK5 is activated selectively by dual phosphorylation on Thr218 and Tyr220 in the TEY motif by its only upstream kinase, MEK5, a member of the MEK |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259825 |
Tyr221 |
HQYFMTEyVATRWYR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20667468 |
ERK5 is a member of the mitogen-activated protein kinase (MAPK) family that, after stimulation, is activated selectively by dual phosphorylation in the TEY motif by MAPK kinase 5 (MEK5). ERK5 is activated selectively by dual phosphorylation on Thr218 and Tyr220 in the TEY motif by its only upstream kinase, MEK5, a member of the MEK |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255453 |
|
|
Homo sapiens |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 23612709 |
The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusion |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
BRAF | up-regulates quantity
phosphorylation
|
MAPK7 |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278352 |
Thr219 |
AEHQYFMtEYVATRW |
Homo sapiens |
|
| pmid |
sentence |
| 29483645 |
Our data indicate that oncogenic BRAF increases ERK5 protein level, phosphorylation at several residues and kinase activity.|Overexpression of oncogenic BRAF induced ERK5 phosphorylation at Thr218 and Tyr220, although to a lower level than that induced by MEK5DD. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278353 |
Tyr221 |
HQYFMTEyVATRWYR |
Homo sapiens |
|
| pmid |
sentence |
| 29483645 |
Our data indicate that oncogenic BRAF increases ERK5 protein level, phosphorylation at several residues and kinase activity.|Overexpression of oncogenic BRAF induced ERK5 phosphorylation at Thr218 and Tyr220, although to a lower level than that induced by MEK5DD. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK7 | up-regulates
phosphorylation
|
ETS1 |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88666 |
Thr38 |
CADVPLLtPSSKEMM |
Homo sapiens |
|
| pmid |
sentence |
| 12048211 |
9-cis retinoid x receptor alpha (rxr alpha) interacted with erk2 but not erk5 in intact cells, whereas ets-1 interacted preferentially with erk5. Increased phosphorylation of rxr alpha and ets-1 was detected in response to 1,25d. Activated erk2 and erk5 specifically phosphorylated rxr alpha and ets-1, respectively.Mutagenesis of ets-1 (t38a) reduced cyp24 promoter activity to levels observed with the dominant-negative mek5(a) and inhibited erk5-directed phosphorylation. Mutated rxr alpha (s260a) inhibited 1,25d-induced cyp24 promoter activity and abolished phosphorylation by activated erk2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPRR | down-regulates activity
dephosphorylation
|
MAPK7 |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248721 |
Tyr221 |
HQYFMTEyVATRWYR |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 12042304 |
In this study we concentrated on whether and how PTP-SL, a kinase-interacting motif-containing PTP, might be involved in the down-regulation of the ERK5 signal|Whereas inactivation of ERK5 by PTP-SL monitored in vitro is most probably simply due to the dephosphorylation of tyrosine 220 in the activating TEY motif |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
MAP2K5 | up-regulates
phosphorylation
|
MAPK7 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104631 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12912994 |
Mek5 is the mapk kinase that phosphorylates and activates erk5 in response to growth factors, oxidative stress, and hyperosmotic conditions. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113770 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11782488 |
Kato et al. reported that mek5 specifically activates bmk1 but not other mammalian map kinasesin vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK7 | up-regulates quantity by expression 
transcriptional regulation
|
KLF2 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255454 |
|
|
Homo sapiens |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 23612709 |
The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
SL-327 | down-regulates
chemical inhibition
|
MAPK7 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104936 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11160424 |
Pd98059, sl327, and u0126 have been extensively used to implicate erk1/2 in neuroplasticity (impey et al., 1999) and neuronal survival (villalba and journot, 1997;meyerfranke et al., 1998;skaper et al., 1998;anderson and tolkovsky, 1999;singer et al., 1999;bi et al., 2000). Interestingly, erk5 activation by egf in cos7 cells is also blocked by these inhibitors, (kamakura et al., 1999), suggesting that the erk5 pathway may also regulate cellular processes credited previously to erk1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
U0126 | down-regulates
chemical inhibition
|
MAPK7 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-104945 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11160424 |
Pd98059, sl327, and u0126 have been extensively used to implicate erk1/2 in neuroplasticity and neuronal survival. Interestingly, erk5 activation by egf in cos7 cells is also blocked by these inhibitors suggesting that the erk5 pathway may also regulate cellular processes credited previously to erk1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
MAPK7 | down-regulates
phosphorylation
|
PML |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167947 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 20832753 |
We found that bmk1 interacted with promyelocytic leukemia protein (pml), and inhibited its tumor-suppressor function through phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK7 | up-regulates activity
phosphorylation
|
NEUROG1 |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278364 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19365559 |
Activation of ERK5 potentiates while inhibition of ERK5 attenuates Neurog1 stimulated neurogenesis.|ERK5 directly phosphorylated Neurog1 in vitro and modulated the transcriptional and pro-neural activity of Neurog1 in cortical progenitors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
U0126 | down-regulates 
|
MAPK7 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113782 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11782488 |
Bmk1activation by h2o2 was inhibited by both pd98059 and u0126, which were reported to inhibit mek5 as well as mek1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK7 | up-regulates quantity by expression
transcriptional regulation
|
KLF4 |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255455 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23612709 |
The MEK5-dependent activation of ERK5 promotes binding of the transcription factor SP1 to the promoter of the genes encoding the transcription factors Klf2 and Klf4, leading to their increased abundance. Subsequently, Klf2 and Klf4 bind to the Npnt promoter and induce the production of nephronectin during myoblast fusion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP6 | down-regulates activity
dephosphorylation
|
MAPK7 |
0.644 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277007 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18280112 |
However, whilst the interaction itself might be difficult to monitor, DUSP6 should still be able to promote the de-phosphorylation of ERK5 in cells if it is an ERK5 phosphatase.To test this HEK293 cells were transiently transfected with HA-ERK2 or HA-ERK5 together with EGFP-MEK1E (a constitutively active version of MEK1) or EGFP-MEK5D (a constitutively active version of MEK5).|Whilst one can envisage scenarios in which the interaction between DUSPs and their substrates might be transient, DUSP6 should still be able to promote the de-phosphorylation and inactivation of ERK5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hydrogen peroxide | up-regulates
|
MAPK7 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113758 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11782488 |
These findings suggest that c-src mediated bmk1 activation by h(2)o(2) may counteract ischemic cellular damage probably through the activation of mef2c transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
MAPK7 | up-regulates activity
binding
|
PPARG |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278108 |
|
|
Homo sapiens |
Endothelial Cell |
| pmid |
sentence |
| 16835228 |
In endothelial cells, flow-mediated activation of ERK5 has been shown to lead to activation of PPAR gamma by direct binding to the hinge-helix region of PPAR gamma |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
2-(2-amino-3-methoxyphenyl)chromen-4-one | down-regulates
chemical inhibition
|
MAPK7 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113773 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11782488 |
Bmk1 activation by h2o2 was inhibited by both pd98059 and u0126, which were reported to inhibit mek5 as well as mek1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
SRC | up-regulates
|
MAPK7 |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113779 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11782488 |
C-src was suggested to be involved in bmk1 activation from the experiments with herbimycin a and pp2, specific inhibitors of src family kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
3.0
MAPK7
- 
- 