Summary

Name MAPK7
Full Name Mitogen-activated protein kinase 7
Synonyms MAP kinase 7, MAPK 7, Big MAP kinase 1, BMK-1, Extracellular signal-regulated kinase 5, ERK-5 | BMK1, ERK5, PRKM7
Primary ID Q13164
Links - -
Type protein
Relations 25
Inhibitors 2-(2-amino-3-methoxyphenyl)chromen-4-one; SL-327; U0126
Function Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation MAP2K5 0.33
Publications: 4 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation MEF2D 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GJA1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MEF2A 0.39
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MEF2C 0.41
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates img/direct-activation.png phosphorylation SGK1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ETS1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK7 0.08
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/indirect-activation.png MAPK7 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK7 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation PML 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF4 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK7 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/indirect-activation.png MAPK7 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK7 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/indirect_inhibition.png MAPK7 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK7 0.51
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png phosphorylation MAPK7 0.26
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF2 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle