Entity Details

Name BRAF_Tyr221
ID Q13164
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAP2K5MAPK7Tyr221HQYFMTEyVATRWYRphosphorylation
up-regulates activity		20667468SIGNOR-259825
PTPRRMAPK7Tyr221HQYFMTEyVATRWYRdephosphorylation
down-regulates activity		12042304SIGNOR-248721
BRAFMAPK7Tyr221HQYFMTEyVATRWYRphosphorylation
up-regulates quantity		29483645SIGNOR-278353
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAP2K5phosphorylation
up-regulates
→
MAPK7
PTyr221		phosphorylation
up-regulates
→		MAPK720667468SIGNOR-259825
PTPRRdephosphorylation
down-regulates
⊣
MAPK7
PTyr221		dephosphorylation
up-regulates
→		MAPK712042304SIGNOR-248721
BRAFphosphorylation
up-regulates
→
MAPK7
PTyr221		phosphorylation
up-regulates
→		MAPK729483645SIGNOR-278353
Regulator Mechanism/Effect Target SIGNOR-ID
MAP2K5phosphorylation
→
up-regulates activity 		MAPK7SIGNOR-259825
PTPRRdephosphorylation
→
down-regulates activity 		MAPK7SIGNOR-248721
BRAFphosphorylation
→
up-regulates quantity 		MAPK7SIGNOR-278353