Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAP3K1	MAP2K7	Ser271	ISGRLVDsKAKTRSA	phosphorylation up-regulates	9312068	SIGNOR-51207
MAP3K1	MAP2K7	Thr275	LVDSKAKtRSAGCAA	phosphorylation up-regulates	9312068	SIGNOR-51211
MAP3K1	MAP2K7	–		phosphorylation up-regulates activity	17110930	SIGNOR-274147
MAP3K1	IKBKB	–		phosphorylation up-regulates activity	9630230	SIGNOR-279339
MAP3K1	STAT3	Ser727	NTIDLPMsPRTLDSL	phosphorylation up-regulates activity	17563747	SIGNOR-236346
MAP3K1	MAP2K4	Thr261	LVDSIAKtRDAGCRP	phosphorylation up-regulates activity	9712898	SIGNOR-236380
MAP3K1	MAP2K4	–		phosphorylation up-regulates activity	9712898	SIGNOR-236376
MAP3K1	NOTCH1	–		phosphorylation down-regulates activity	27806347	SIGNOR-279628
MAP3K1	MAP2K6	Thr211	LVDSVAKtIDAGCKP	phosphorylation up-regulates	9712898	SIGNOR-59679
MAP3K1	MAP2K1	Ser218	VSGQLIDsMANSFVG	phosphorylation up-regulates activity	8131746	SIGNOR-235587
MAP3K1	MAP2K1	Ser222	LIDSMANsFVGTRSY	phosphorylation up-regulates activity	8131746	SIGNOR-235564
MAP3K1	FADD	Ser194	QNRSGAMsPMSWNSD	phosphorylation down-regulates activity	15001534	SIGNOR-123168
MAP3K1	SMAD2	–		phosphorylation up-regulates activity	10647776	SIGNOR-279064
MAP3K1	CRTC1	–		phosphorylation up-regulates	18784253	SIGNOR-180816
MAP3K1	MEK1/2	–		phosphorylation up-regulates activity	8131746	SIGNOR-244881

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAP3K1	phosphorylation up-regulates →	MAP2K7 PSer271	phosphorylation up-regulates →	MAP2K7	9312068	SIGNOR-51207
MAP3K1	phosphorylation up-regulates →	MAP2K7 PThr275	phosphorylation up-regulates →	MAP2K7	9312068	SIGNOR-51211
MAP3K1	phosphorylation up-regulates →	STAT3 PSer727	phosphorylation up-regulates →	STAT3	17563747	SIGNOR-236346
MAP3K1	phosphorylation up-regulates →	MAP2K4 PThr261	phosphorylation up-regulates →	MAP2K4	9712898	SIGNOR-236380
MAP3K1	phosphorylation up-regulates →	MAP2K6 PThr211	phosphorylation up-regulates →	MAP2K6	9712898	SIGNOR-59679
MAP3K1	phosphorylation up-regulates →	MAP2K1 PSer218	phosphorylation up-regulates →	MAP2K1	8131746	SIGNOR-235587
MAP3K1	phosphorylation up-regulates →	MAP2K1 PSer222	phosphorylation up-regulates →	MAP2K1	8131746	SIGNOR-235564
MAP3K1	phosphorylation up-regulates →	FADD PSer194	phosphorylation down-regulates ⊣	FADD	15001534	SIGNOR-123168

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAP3K1	phosphorylation → up-regulates	MAP2K7	SIGNOR-51207
MAP3K1	phosphorylation → up-regulates	MAP2K7	SIGNOR-51211
MAP3K1	phosphorylation → up-regulates activity	MAP2K7	SIGNOR-274147
MAP3K1	phosphorylation → up-regulates activity	IKBKB	SIGNOR-279339
MAP3K1	phosphorylation → up-regulates activity	STAT3	SIGNOR-236346
MAP3K1	phosphorylation → up-regulates activity	MAP2K4	SIGNOR-236380
MAP3K1	phosphorylation → up-regulates activity	MAP2K4	SIGNOR-236376
MAP3K1	phosphorylation → down-regulates activity	NOTCH1	SIGNOR-279628
MAP3K1	phosphorylation → up-regulates	MAP2K6	SIGNOR-59679
MAP3K1	phosphorylation → up-regulates activity	MAP2K1	SIGNOR-235587
MAP3K1	phosphorylation → up-regulates activity	MAP2K1	SIGNOR-235564
MAP3K1	phosphorylation → down-regulates activity	FADD	SIGNOR-123168
MAP3K1	phosphorylation → up-regulates activity	SMAD2	SIGNOR-279064
MAP3K1	phosphorylation → up-regulates	CRTC1	SIGNOR-180816
MAP3K1	phosphorylation → up-regulates activity	MEK1/2	SIGNOR-244881