| + |
MAP3K1 | down-regulates activity 
phosphorylation
|
FADD |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123168 |
Ser194 |
QNRSGAMsPMSWNSD |
Homo sapiens |
|
| pmid |
sentence |
| 15001534 |
The results clearly show that fadd phosphorylation at ser194 affects functions both upstream and downstream of the mekk1/mkk7/jnk1 pathway and is closely associated with chemosensitivity in prostate cancer cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, TNF-alpha Signaling |
| + |
MAP3K1 | up-regulates activity 
phosphorylation
|
MAP2K1 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235587 |
Ser218 |
VSGQLIDsMANSFVG |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8131746 |
Phosphorylation at ser-218 and ser-222 by map kinase kinase kinases (raf or mekk1) positively regulates mek1 kinase activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235564 |
Ser222 |
LIDSMANsFVGTRSY |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8131746 |
Phosphorylation at ser-218 and ser-222 by map kinase kinase kinases (raf or mekk1) positively regulates mek1 kinase activity. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
MAP3K1 | up-regulates
phosphorylation
|
MAP2K7 |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-51207 |
Ser271 |
ISGRLVDsKAKTRSA |
Homo sapiens |
|
| pmid |
sentence |
| 9312068 |
Here we show that jnkk2, a novel member of the map kinase kinase family, was phosphorylated and activated by mekk1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-51211 |
Thr275 |
LVDSKAKtRSAGCAA |
Homo sapiens |
|
| pmid |
sentence |
| 9312068 |
Here we show that jnkk2, a novel member of the map kinase kinase family, was phosphorylated and activated by mekk1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, TNF-alpha Signaling, Toll like receptors |
| + |
KRAS | up-regulates
phosphorylation, binding
|
MAP3K1 |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-41953 |
Ser67 |
RQLRKVRsVELDQLP |
Homo sapiens |
B-lymphocyte, Lymphoma Cell |
| pmid |
sentence |
| 8649450 |
Activation of ras may lead to two distinct ras-dependent pathways involving either a raf1/mek/mapk module or a mekk/sek/sapk module; jnk/sapk binds to the d domain near the nh2 terminus of mekk1 from approximately residues 6270 (9, 10). Pak1 can phosphorylate mekk1 on serine 67 within its jnk/sapk-binding d domain. Phosphorylation of mekk1 on serine 67 alters the state of the d domain, thereby decreasing its affinity for jnk/sapk. Under these conditions jnk/sapk is not recruited into the mekk1 signaling module. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-92793 |
Ser67 |
RQLRKVRsVELDQLP |
Homo sapiens |
|
| pmid |
sentence |
| 12228228 |
Activation of ras may lead to two distinct ras-dependent pathways involving either a raf1/mek/mapk module or a mekk/sek/sapk module; jnk/sapk binds to the d domain near the nh2 terminus of mekk1 from approximately residues 6270 (9, 10). Pak1 can phosphorylate mekk1 on serine 67 within its jnk/sapk-binding d domain. Phosphorylation of mekk1 on serine 67 alters the state of the d domain, thereby decreasing its affinity for jnk/sapk. Under these conditions jnk/sapk is not recruited into the mekk1 signaling module. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-32620 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7744823 |
Mitogen-activated protein kinase kinase kinase (mekk1) is a serine-threonine kinase that regulates sequential protein kinase pathways involving stress-activated protein kinases and mitogen-activated protein kinases. Mekk1 is activated in response to growth factor stimulation of cells and by expression of activated ras. mekk1 directly binds ras.GTP. Thus, ras interacts with protein kinases of both the raf and mekk families. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
PAK1 | up-regulates activity
phosphorylation
|
MAP3K1 |
0.511 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236006 |
Ser67 |
RQLRKVRsVELDQLP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12228228 |
We found that pak1 phosphorylated mekk1 on serine 67 of its amino-terminal regulatory domain. mekk1 activity was increased modestly following pak phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, Toll like receptors |
| + |
MAP3K1 | up-regulates activity
phosphorylation
|
STAT3 |
0.298 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236346 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 17563747 |
Phosphorylation of s727 induces pin1 binding which increases transcription. Pin1 binding increases stat3 interaction with p300 and dna. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, EBV infection, Macrophage polarization |
| + |
RIPK1 | up-regulates activity
phosphorylation
|
MAP3K1 |
0.426 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108257 |
Ser970 |
HSQCLNSsPLSHHSQ |
Homo sapiens |
|
| pmid |
sentence |
| 11369754 |
These findings strongly suggest that rip phosphorylates mekk1 at ser-957 and ser-994. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Macrophage polarization, SAPK/JNK Signaling, TNF-alpha Signaling |
| + |
MAP3K1 | up-regulates
phosphorylation
|
MAP2K6 |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59679 |
Thr211 |
LVDSVAKtIDAGCKP |
Homo sapiens |
|
| pmid |
sentence |
| 9712898 |
Both wild type and kinase-inactive mutant rip immunoprecipitates can active mkk6 in vitrohe sapks are activated by at least two meks, sapk/erk kinase-1 (sek1, also called mapk-kinase (mkk)) and mkk7 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, Toll like receptors |
| + |
MAP3K1 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.711 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236380 |
Thr261 |
LVDSIAKtRDAGCRP |
Homo sapiens |
|
| pmid |
sentence |
| 9712898 |
The gck-ctd-mekk1 interaction is sufficiently stable to support mekk1 s phosphorylation of its substrate, sek1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236376 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9712898 |
The gck-ctd-mekk1 interaction is sufficiently stable to support mekk1 s phosphorylation of its substrate, SEK1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EGFR Signaling, Macrophage polarization, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TNF-alpha Signaling |
| + |
GRIPAP1 | up-regulates activity
binding
|
MAP3K1 |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260640 |
|
|
Homo sapiens |
HEK-293T Cell, Brain |
| pmid |
sentence |
| 17761173 |
To examine whether GRASP‐1 interacts with MEKK1 and JNK1 in neurons, co‐immunoprecipitation experiments were performed with detergent‐solubilized extracts from cultured cortical neurons. Both antiJNK1 and anti‐MEKK1 antibodies immunoprecipitated GRASP‐1 from neuronal lysates. These results suggest that GRASP‐1 interacts with MEKK1 and JNK1 in neurons. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260607 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 17761173 |
We investigated signal transduction pathways that might lie downstream of GRASP-1 and found that GRASP-1 potently activates JNK pathway signaling, with no effect on ERK signaling. Such JNK pathway activating activity requires binding of GRASP-1 to both JNK and the upstream JNK pathway activator MEKK-1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP4K2 | up-regulates
binding
|
MAP3K1 |
0.54 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59682 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9712898 |
The mekk1 associated with the gck carboxyl terminus is catalytically active. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SAPK/JNK Signaling |
| + |
RIPK1 | up-regulates
phosphorylation
|
MAP3K1 |
0.426 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108260 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11369754 |
These findings strongly suggest that rip phosphorylates mekk1 at ser-957 and ser-994. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Macrophage polarization, SAPK/JNK Signaling, TNF-alpha Signaling |
| + |
MAP4K3 | up-regulates
phosphorylation
|
MAP3K1 |
0.425 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-61814 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9820741 |
With regard to at least mekk1, serine/threonine kinases such as nik,glkand hpk1 appear also to be important for regulation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ub:E2 | up-regulates activity
ubiquitination
|
MAP3K1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271008 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRAF2 | up-regulates
binding
|
MAP3K1 |
0.699 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67552 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10346818 |
Oligomerization of the traf2 effector domain results in specific binding to mekk1, a protein kinase capable of jnk, p38, and ikk activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179476 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18635759 |
Traf2, ubc13, and ikkgamma were required for complex assembly and activation of mekk1 and mapk cascades. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | SAPK/JNK Signaling, TNF-alpha Signaling |
| + |
MAP4K5 | up-regulates 
|
MAP3K1 |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53779 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9405407 |
Here we report the identification of a tnf-responsive serine/threonine protein kinase termed gck related (gckr) that likely signals via mitogen-activated protein kinase (mapk)/extracellular signal-regulated kinase (erk) kinase kinase 1 (mekk1) to activate the sapk pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP4K1 | up-regulates
phosphorylation
|
MAP3K1 |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43996 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8824585 |
Hpk1 binds and phosphorylates mekk1 directly, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SAPK/JNK Signaling |
| + |
MAP3K1 | down-regulates quantity by destabilization
polyubiquitination
|
ERK1/2 |
0.524 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272609 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12049732 |
ERK1/2 MAP kinases are important regulators in cellular signaling, whose activity is normally reversibly regulated by threonine-tyrosine phosphorylation. In contrast, we have found that stress-induced ERK1/2 activity is downregulated by ubiquitin/proteasome-mediated degradation of ERK1/2. The PHD domain of MEKK1, a RING finger-like structure, exhibited E3 ubiquitin ligase activity toward ERK2 in vitro and in vivo. Therefore, MEKK1 functions not only as an upstream activator of the ERK and JNK through its kinase domain, but also as an E3 ligase through its PHD domain, providing a negative regulatory mechanism for decreasing ERK1/2 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EGFR Signaling, SARS-CoV MAPK PERTURBATION, Toll like receptors |
| + |
AXIN1 | up-regulates
binding
|
MAP3K1 |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77591 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10829020 |
We found that in contrast to axin, dvl2 activation of jnk does not require mekk1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K1 | up-regulates activity
phosphorylation
|
MEK1/2 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244881 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8131746 |
Phosphorylation at ser-218 and ser-222 by map kinase kinase kinases (raf or mekk1) positively regulates mek1 kinase activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | COVID-19 Causal Network, EGFR Signaling, SARS-CoV MAPK PERTURBATION, Toll like receptors |
| + |
MAP4K4 | up-regulates
phosphorylation
|
MAP3K1 |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-44040 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8824585 |
Hpk1 binds and phosphorylates mekk1 directly |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD7 | down-regulates 
|
MAP3K1 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-65572 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10085121 |
Overexpression of smad7 can inhibit the mekk-1-mediated stimulation of smad2 transcriptional activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network |
| + |
MAP3K1 | up-regulates activity
phosphorylation
|
MAP2K7 |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274147 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17110930 |
Upon TNFα stimulation, MEKK1, ASK1, and TAK1 phosphorylate and activate MKK7, which in turn activates JNK |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, TNF-alpha Signaling, Toll like receptors |
| + |
MAPK8IP3 | up-regulates
binding
|
MAP3K1 |
0.521 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71471 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10523642 |
Overexpression of full-length jsap1 in cos-7 cells led to a considerable enhancement of jnk3 activation, and modest enhancement of jnk1 and jnk2 activation, by the mekk1-sek1 pathwaythe regions of jsap1 that bound jnk, sek1, and mekk1 were distinct from one another. Jnk and mekk1 also bound jsap1 in vitro, suggesting that these interactions are direct. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K1 | up-regulates
phosphorylation
|
CRTC1 |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180816 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18784253 |
We report on the activation oftorc1through mekk1-mediated phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MAP3K1
- 
- 