Summary

Name MAP3K1
Full Name Mitogen-activated protein kinase kinase kinase 1
Synonyms MAPK/ERK kinase kinase 1, MEK kinase 1, MEKK 1 | MAPKKK1, MEKK, MEKK1
Primary ID Q13233
Links - -
Type protein
Relations 31
Pathways COVID-19 Causal Network, EGFR Signaling, EBV infection, Macrophage polarization, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TNF-alpha Signaling, Toll like receptors
Function Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation FADD 0.501
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K1 0.659
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation MAP2K7 0.722
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, TNF-alpha Signaling, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K1 0.536
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.291
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, EBV infection, Macrophage polarization
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K1 0.453
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Macrophage polarization, SAPK/JNK Signaling, TNF-alpha Signaling
+ up-regulates img/direct-activation.png phosphorylation MAP2K6 0.452
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K4 0.728
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EGFR Signaling, Macrophage polarization, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TNF-alpha Signaling
+ up-regulates img/indirect-activation.png MAP3K1 0.452
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP3K1 0.45
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAP3K1 0.313
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP3K1 0.452
Publications: 1 Organism: Homo Sapiens
Pathways:EBV infection, SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png ubiquitination MAP3K1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K1 0.717
Publications: 2 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling, TNF-alpha Signaling
+ up-regulates img/direct-activation.png phosphorylation CRTC1 0.322
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K1 0.517
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MEK1/2 0.659
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, EGFR Signaling, SARS-CoV MAPK PERTURBATION, Toll like receptors
+ down-regulates img/indirect_inhibition.png MAP3K1 0.265
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ up-regulates img/direct-activation.png phosphorylation MAP3K1 0.453
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Macrophage polarization, SAPK/JNK Signaling, TNF-alpha Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination ERK1/2 0.512
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EGFR Signaling, SARS-CoV MAPK PERTURBATION, Toll like receptors
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation MAP3K1 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K7 0.722
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, TNF-alpha Signaling, Toll like receptors
+ up-regulates img/direct-activation.png binding MAP3K1 0.541
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K1 0.563
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates img/direct-activation.png phosphorylation MAP3K1 0.556
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K1 0.367
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION