| Name | MAP3K1 |
| ID | Q13233 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 1243-1508 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP4K1 | MAP3K1 | – | phosphorylation up-regulates | 8824585 | SIGNOR-43996 | |
| RIPK1 | MAP3K1 | Ser970 | HSQCLNSsPLSHHSQ | phosphorylation up-regulates activity | 11369754 | SIGNOR-108257 |
| RIPK1 | MAP3K1 | – | phosphorylation up-regulates | 11369754 | SIGNOR-108260 | |
| ABL1 | MAP3K1 | – | phosphorylation up-regulates activity | 10866655 | SIGNOR-279672 | |
| PAK1 | MAP3K1 | Ser67 | RQLRKVRsVELDQLP | phosphorylation up-regulates activity | 12228228 | SIGNOR-236006 |
| MAP4K3 | MAP3K1 | – | phosphorylation up-regulates | 9820741 | SIGNOR-61814 | |
| MAP4K4 | MAP3K1 | – | phosphorylation up-regulates | 8824585 | SIGNOR-44040 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RIPK1 | phosphorylation up-regulates → | MAP3K1 PSer970 | phosphorylation up-regulates → | MAP3K1 | 11369754 | SIGNOR-108257 |
| PAK1 | phosphorylation up-regulates → | MAP3K1 PSer67 | phosphorylation up-regulates → | MAP3K1 | 12228228 | SIGNOR-236006 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP4K1 | phosphorylation → up-regulates | MAP3K1 | SIGNOR-43996 |
| RIPK1 | phosphorylation → up-regulates activity | MAP3K1 | SIGNOR-108257 |
| RIPK1 | phosphorylation → up-regulates | MAP3K1 | SIGNOR-108260 |
| ABL1 | phosphorylation → up-regulates activity | MAP3K1 | SIGNOR-279672 |
| PAK1 | phosphorylation → up-regulates activity | MAP3K1 | SIGNOR-236006 |
| MAP4K3 | phosphorylation → up-regulates | MAP3K1 | SIGNOR-61814 |
| MAP4K4 | phosphorylation → up-regulates | MAP3K1 | SIGNOR-44040 |