Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDK2	SKP2	Ser64 View in OncoXplorer	SNLGHPEsPPRKRLK	phosphorylation up-regulates quantity by stabilization	18239684	SIGNOR-249173
PIM1	SKP2	Ser64 View in OncoXplorer	SNLGHPEsPPRKRLK	phosphorylation up-regulates activity	20663873	SIGNOR-259818
PIM1	SKP2	Thr417	WGIKCRLtLQKPSCL	phosphorylation up-regulates activity	20663873	SIGNOR-259817
PIM1	SKP2	Ser72	PPRKRLKsKGSDKDF	phosphorylation up-regulates activity	20663873	SIGNOR-259819
AKT1	SKP2	Ser72	PPRKRLKsKGSDKDF	phosphorylation down-regulates activity	19270695	SIGNOR-278274
CDC14B	SKP2	Ser64 View in OncoXplorer	SNLGHPEsPPRKRLK	dephosphorylation down-regulates quantity by destabilization	18239684	SIGNOR-248333

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDK2	phosphorylation up-regulates →	SKP2 PSer64	phosphorylation up-regulates →	SKP2	18239684	SIGNOR-249173
PIM1	phosphorylation up-regulates →	SKP2 PSer64	phosphorylation up-regulates →	SKP2	20663873	SIGNOR-259818
PIM1	phosphorylation up-regulates →	SKP2 PThr417	phosphorylation up-regulates →	SKP2	20663873	SIGNOR-259817
PIM1	phosphorylation up-regulates →	SKP2 PSer72	phosphorylation up-regulates →	SKP2	20663873	SIGNOR-259819
AKT1	phosphorylation up-regulates →	SKP2 PSer72	phosphorylation down-regulates ⊣	SKP2	19270695	SIGNOR-278274
CDC14B	dephosphorylation down-regulates ⊣	SKP2 PSer64	dephosphorylation up-regulates →	SKP2	18239684	SIGNOR-248333

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDK2	phosphorylation → up-regulates quantity by stabilization	SKP2	SIGNOR-249173
PIM1	phosphorylation → up-regulates activity	SKP2	SIGNOR-259818
PIM1	phosphorylation → up-regulates activity	SKP2	SIGNOR-259817
PIM1	phosphorylation → up-regulates activity	SKP2	SIGNOR-259819
AKT1	phosphorylation → down-regulates activity	SKP2	SIGNOR-278274
CDC14B	dephosphorylation down-regulates quantity by destabilization	SKP2	SIGNOR-248333