Summary

Name SKP2
Full Name S-phase kinase-associated protein 2
Synonyms Cyclin-A/CDK2-associated protein p45, F-box protein Skp2, F-box/LRR-repeat protein 1, p45skp2 | FBXL1
Primary ID Q13309
Links - -
Type protein
Relations 13
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation SKP2 0.28
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation SKP2
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation SKP2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination MYC 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination SMAD4 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination CDKN1A 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DAB2IP 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination CDKN1B 0.37
Publications: 2 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SCF-SKP2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png SKP2 0.14
Publications: 1 Organism: Homo Sapiens