Summary

Name SKP2
Full Name S-phase kinase-associated protein 2
Synonyms Cyclin-A/CDK2-associated protein p45, F-box protein Skp2, F-box/LRR-repeat protein 1, p45skp2 | FBXL1
Primary ID Q13309
Links - -
Type protein
Relations 25
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:16262255, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:17962192, PubMed:22770219, PubMed:32267835). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (By similarity). Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:11931757, PubMed:12435635, PubMed:12769844, PubMed:12840033, PubMed:15342634, PubMed:15668399, PubMed:15949444, PubMed:16103164, PubMed:17962192, PubMed:16581786, PubMed:16951159, PubMed:17908926, PubMed:32267835). Degradation of TAL1 also requires STUB1 (PubMed:17962192). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (PubMed:16262255). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (PubMed:22770219).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SKP2 0.347
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation SKP2 0.365
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation SKP2 0.791
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination SKP2 0.917
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination IDH1 0.2
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CDT1 0.685
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CCNE1 0.693
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding Cullin 1-RBX1-Skp1 0.917
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png SKP2 0.262
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination CDKN1B 0.757
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding NUDT1 0.257
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination CDKN1A 0.761
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination MYBL2 0.388
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DAB2IP 0.273
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination MYC 0.726
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination SMAD4 0.408
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SCF-SKP2 0.924
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination IDH2 0.2
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CCND1 0.577
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding Cullin 1-RBX1-Skp1 0.917
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding CYGB 0.2
Publications: 1 Organism: Homo Sapiens