| Name | GRB10 |
| ID | Q13322 |
| Role | substrate |
| Enzymatic Domains |
Ras-associating 166-250 PROSITE-ProRule
PH 290-399 PROSITE-ProRule
SH2 493-574 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | GRB10 | Ser150 | PELCGPGsPPVLTPG | phosphorylation up-regulates | 15952796 | SIGNOR-138171 |
| FYN | GRB10 | Tyr67 | NASLESLySACSMQS | phosphorylation down-regulates | 10871840 | SIGNOR-78702 |
| MAPK1 | GRB10 | Ser150 | PELCGPGsPPVLTPG | phosphorylation up-regulates | 15952796 | SIGNOR-138163 |
| Gbeta | GRB10 | – | phosphorylation up-regulates | 15952796 | SIGNOR-270077 | |
| MAPK1 | GRB10 | Ser476 | MNILGSQsPLHPSTL | phosphorylation up-regulates | 15952796 | SIGNOR-138167 |
| SRC | GRB10 | Tyr67 | NASLESLySACSMQS | phosphorylation down-regulates | 10871840 | SIGNOR-78706 |
| ERK1/2 | GRB10 | – | phosphorylation up-regulates | 15952796 | SIGNOR-270178 | |
| MAPK3 | GRB10 | Ser418 | QQRKALLsPFSTPVR | phosphorylation unknown | 15952796 | SIGNOR-249406 |
| MTOR | GRB10 | – | phosphorylation up-regulates | 21659604 | SIGNOR-174071 | |
| MAPK1 | GRB10 | Ser418 | QQRKALLsPFSTPVR | phosphorylation unknown | 15952796 | SIGNOR-249405 |
| mTORC1 | GRB10 | – | phosphorylation up-regulates | 21659604 | SIGNOR-217063 | |
| MAPK3 | GRB10 | Ser476 | MNILGSQsPLHPSTL | phosphorylation up-regulates | 15952796 | SIGNOR-138175 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | GRB10 PSer150 | phosphorylation up-regulates → | GRB10 | 15952796 | SIGNOR-138171 |
| FYN | phosphorylation up-regulates → | GRB10 PTyr67 | phosphorylation down-regulates ⊣ | GRB10 | 10871840 | SIGNOR-78702 |
| MAPK1 | phosphorylation up-regulates → | GRB10 PSer150 | phosphorylation up-regulates → | GRB10 | 15952796 | SIGNOR-138163 |
| MAPK1 | phosphorylation up-regulates → | GRB10 PSer476 | phosphorylation up-regulates → | GRB10 | 15952796 | SIGNOR-138167 |
| SRC | phosphorylation up-regulates → | GRB10 PTyr67 | phosphorylation down-regulates ⊣ | GRB10 | 10871840 | SIGNOR-78706 |
| MAPK3 | phosphorylation up-regulates → | GRB10 PSer418 | phosphorylation down-regulates ⊣ | GRB10 | 15952796 | SIGNOR-249406 |
| MAPK1 | phosphorylation up-regulates → | GRB10 PSer418 | phosphorylation down-regulates ⊣ | GRB10 | 15952796 | SIGNOR-249405 |
| MAPK3 | phosphorylation up-regulates → | GRB10 PSer476 | phosphorylation up-regulates → | GRB10 | 15952796 | SIGNOR-138175 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates | GRB10 | SIGNOR-138171 |
| FYN | phosphorylation down-regulates | GRB10 | SIGNOR-78702 |
| MAPK1 | phosphorylation → up-regulates | GRB10 | SIGNOR-138163 |
| Gbeta | phosphorylation → up-regulates | GRB10 | SIGNOR-270077 |
| MAPK1 | phosphorylation → up-regulates | GRB10 | SIGNOR-138167 |
| SRC | phosphorylation down-regulates | GRB10 | SIGNOR-78706 |
| ERK1/2 | phosphorylation → up-regulates | GRB10 | SIGNOR-270178 |
| MAPK3 | phosphorylation → unknown | GRB10 | SIGNOR-249406 |
| MTOR | phosphorylation → up-regulates | GRB10 | SIGNOR-174071 |
| MAPK1 | phosphorylation → unknown | GRB10 | SIGNOR-249405 |
| mTORC1 | phosphorylation → up-regulates | GRB10 | SIGNOR-217063 |
| MAPK3 | phosphorylation → up-regulates | GRB10 | SIGNOR-138175 |