| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | PPP2R5C | Ser337 | QLAKCVSsPHFQVAE | phosphorylation down-regulates | 16456541 | SIGNOR-144317 |
| Gbeta | PPP2R5C | – | phosphorylation down-regulates | 16456541 | SIGNOR-270101 | |
| CHEK2 | PPP2R5C | – | phosphorylation up-regulates | 15380617 | SIGNOR-129255 | |
| ERK1/2 | PPP2R5C | – | phosphorylation down-regulates | 16456541 | SIGNOR-270196 | |
| MAPK1 | PPP2R5C | Ser337 | QLAKCVSsPHFQVAE | phosphorylation down-regulates | 16456541 | SIGNOR-144313 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | PPP2R5C PSer337 | phosphorylation down-regulates ⊣ | PPP2R5C | 16456541 | SIGNOR-144317 |
| MAPK1 | phosphorylation up-regulates → | PPP2R5C PSer337 | phosphorylation down-regulates ⊣ | PPP2R5C | 16456541 | SIGNOR-144313 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation down-regulates | PPP2R5C | SIGNOR-144317 |
| Gbeta | phosphorylation down-regulates | PPP2R5C | SIGNOR-270101 |
| CHEK2 | phosphorylation → up-regulates | PPP2R5C | SIGNOR-129255 |
| ERK1/2 | phosphorylation down-regulates | PPP2R5C | SIGNOR-270196 |
| MAPK1 | phosphorylation down-regulates | PPP2R5C | SIGNOR-144313 |
