Summary

Name PPP2R5C
Full Name Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Synonyms PP2A B subunit isoform B'-gamma, PP2A B subunit isoform B56-gamma, PP2A B subunit isoform PR61-gamma, PP2A B subunit isoform R5-gamma, Renal carcinoma antigen NY-REN-29 | KIAA0044
Primary ID Q13362
Links - -
Type protein
Relations 11
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation PPP2R5C 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PPP2R5C 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation ATF1 0.14
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PPP2R5C 0.48
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RPS6KB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PPP2R5C 0.31
Publications: 1 Organism: Homo Sapiens