| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SYK | IKZF1 | Ser364 | GTPRSNHsAQDSAVE | phosphorylation up-regulates | 23071339 | SIGNOR-199100 |
| CSNK2A1 | IKZF1 | Ser13 | GQDMSQVsGKESPPV | phosphorylation down-regulates | 21750978 | SIGNOR-174824 |
| PPP1CC | IKZF1 | – | dephosphorylation up-regulates | 21750978 | SIGNOR-174865 | |
| CSNK2A1 | IKZF1 | Thr23 | ESPPVSDtPDEGDEP | phosphorylation down-regulates | 21750978 | SIGNOR-174836 |
| PPP1CB | IKZF1 | – | dephosphorylation up-regulates | 21750978 | SIGNOR-174862 | |
| PP1 | IKZF1 | – | dephosphorylation up-regulates | 21750978 | SIGNOR-264663 | |
| CSNK2A1 | IKZF1 | Ser295 | LSDTPYDsSASYEKE | phosphorylation down-regulates | 21750978 | SIGNOR-174828 |
| PPP1CA | IKZF1 | – | dephosphorylation up-regulates | 21750978 | SIGNOR-174859 | |
| SYK | IKZF1 | Ser361 | LAEGTPRsNHSAQDS | phosphorylation up-regulates | 23071339 | SIGNOR-199096 |
| BTK | IKZF1 | Ser215 | RSYKQRSsLEEHKER | phosphorylation up-regulates activity | 23977012 | SIGNOR-279442 |
| CSNK2B | IKZF1 | Ser13 | GQDMSQVsGKESPPV | phosphorylation down-regulates | 21750978 | SIGNOR-174844 |
| CSNK2A1 | IKZF1 | Ser63 | NVKVETQsDEENGRA | phosphorylation down-regulates | 21750978 | SIGNOR-174832 |
| CSNK2A1 | IKZF1 | Ser101 | GSHRDQGsSALSGVG | phosphorylation down-regulates | 21750978 | SIGNOR-174820 |
| BTK | IKZF1 | Ser214 | GRSYKQRsSLEEHKE | phosphorylation up-regulates activity | 23977012 | SIGNOR-279443 |
| CSNK2B | IKZF1 | Ser101 | GSHRDQGsSALSGVG | phosphorylation down-regulates | 21750978 | SIGNOR-174840 |
| CSNK2B | IKZF1 | Thr23 | ESPPVSDtPDEGDEP | phosphorylation down-regulates | 21750978 | SIGNOR-174856 |
| CSNK2B | IKZF1 | Ser295 | LSDTPYDsSASYEKE | phosphorylation down-regulates | 21750978 | SIGNOR-174848 |
| CSNK2B | IKZF1 | Ser63 | NVKVETQsDEENGRA | phosphorylation down-regulates | 21750978 | SIGNOR-174852 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SYK | phosphorylation up-regulates → | IKZF1 PSer364 | phosphorylation up-regulates → | IKZF1 | 23071339 | SIGNOR-199100 |
| CSNK2A1 | phosphorylation up-regulates → | IKZF1 PSer13 | phosphorylation down-regulates ⊣ | IKZF1 | 21750978 | SIGNOR-174824 |
| CSNK2A1 | phosphorylation up-regulates → | IKZF1 PThr23 | phosphorylation down-regulates ⊣ | IKZF1 | 21750978 | SIGNOR-174836 |
| CSNK2A1 | phosphorylation up-regulates → | IKZF1 PSer295 | phosphorylation down-regulates ⊣ | IKZF1 | 21750978 | SIGNOR-174828 |
| SYK | phosphorylation up-regulates → | IKZF1 PSer361 | phosphorylation up-regulates → | IKZF1 | 23071339 | SIGNOR-199096 |
| BTK | phosphorylation up-regulates → | IKZF1 PSer215 | phosphorylation up-regulates → | IKZF1 | 23977012 | SIGNOR-279442 |
| CSNK2B | phosphorylation up-regulates → | IKZF1 PSer13 | phosphorylation down-regulates ⊣ | IKZF1 | 21750978 | SIGNOR-174844 |
| CSNK2A1 | phosphorylation up-regulates → | IKZF1 PSer63 | phosphorylation down-regulates ⊣ | IKZF1 | 21750978 | SIGNOR-174832 |
| CSNK2A1 | phosphorylation up-regulates → | IKZF1 PSer101 | phosphorylation down-regulates ⊣ | IKZF1 | 21750978 | SIGNOR-174820 |
| BTK | phosphorylation up-regulates → | IKZF1 PSer214 | phosphorylation up-regulates → | IKZF1 | 23977012 | SIGNOR-279443 |
| CSNK2B | phosphorylation up-regulates → | IKZF1 PSer101 | phosphorylation down-regulates ⊣ | IKZF1 | 21750978 | SIGNOR-174840 |
| CSNK2B | phosphorylation up-regulates → | IKZF1 PThr23 | phosphorylation down-regulates ⊣ | IKZF1 | 21750978 | SIGNOR-174856 |
| CSNK2B | phosphorylation up-regulates → | IKZF1 PSer295 | phosphorylation down-regulates ⊣ | IKZF1 | 21750978 | SIGNOR-174848 |
| CSNK2B | phosphorylation up-regulates → | IKZF1 PSer63 | phosphorylation down-regulates ⊣ | IKZF1 | 21750978 | SIGNOR-174852 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SYK | phosphorylation → up-regulates | IKZF1 | SIGNOR-199100 |
| CSNK2A1 | phosphorylation down-regulates | IKZF1 | SIGNOR-174824 |
| PPP1CC | dephosphorylation → up-regulates | IKZF1 | SIGNOR-174865 |
| CSNK2A1 | phosphorylation down-regulates | IKZF1 | SIGNOR-174836 |
| PPP1CB | dephosphorylation → up-regulates | IKZF1 | SIGNOR-174862 |
| PP1 | dephosphorylation → up-regulates | IKZF1 | SIGNOR-264663 |
| CSNK2A1 | phosphorylation down-regulates | IKZF1 | SIGNOR-174828 |
| PPP1CA | dephosphorylation → up-regulates | IKZF1 | SIGNOR-174859 |
| SYK | phosphorylation → up-regulates | IKZF1 | SIGNOR-199096 |
| BTK | phosphorylation → up-regulates activity | IKZF1 | SIGNOR-279442 |
| CSNK2B | phosphorylation down-regulates | IKZF1 | SIGNOR-174844 |
| CSNK2A1 | phosphorylation down-regulates | IKZF1 | SIGNOR-174832 |
| CSNK2A1 | phosphorylation down-regulates | IKZF1 | SIGNOR-174820 |
| BTK | phosphorylation → up-regulates activity | IKZF1 | SIGNOR-279443 |
| CSNK2B | phosphorylation down-regulates | IKZF1 | SIGNOR-174840 |
| CSNK2B | phosphorylation down-regulates | IKZF1 | SIGNOR-174856 |
| CSNK2B | phosphorylation down-regulates | IKZF1 | SIGNOR-174848 |
| CSNK2B | phosphorylation down-regulates | IKZF1 | SIGNOR-174852 |
