Summary

Name IKZF1
Full Name DNA-binding protein Ikaros
Synonyms Ikaros family zinc finger protein 1, Lymphoid transcription factor LyF-1 | IK1, IKAROS, LYF1, ZNFN1A1
Primary ID Q13422
Links - -
Type protein
Relations 17
Function Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation IKZF1 0.41
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation IKZF1
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IKZF1 0.26
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination IKZF1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation IKZF1 0.40
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation IKZF1 0.50
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation IKZF1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LNPEP 0.45
Publications: 1 Organism: Homo Sapiens