| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP3CA | NFATC2 | Ser175 | SPASSGSsASFISDT | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248682 |
| Calcineurin | NFATC2 | Ser175 | SPASSGSsASFISDT | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252343 |
| PPP3CB | NFATC2 | Ser175 | SPASSGSsASFISDT | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248368 |
| PPP3CC | NFATC2 | Ser175 | SPASSGSsASFISDT | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248513 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer175 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248682 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer175 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252343 |
| PPP3CB | dephosphorylation down-regulates ⊣ | NFATC2 PSer175 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248368 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer175 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248513 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248682 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252343 |
| PPP3CB | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248368 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248513 |
