Summary

Name NFATC2
Full Name Nuclear factor of activated T-cells, cytoplasmic 2
Synonyms NF-ATc2, NFATc2, NFAT pre-existing subunit, NF-ATp, T-cell transcription factor NFAT1 | NFAT1, NFATP
Primary ID Q13469
Links - -
Type protein
Relations 85
Pathways IGF and Myogenesis, SAPK/JNK Signaling
Function Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png dephosphorylation NFATC2
Publications: 16 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation NFATC2
Publications: 15 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates activity img/direct-activation.png dephosphorylation NFATC2
Publications: 15 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates activity img/direct-activation.png dephosphorylation NFATC2
Publications: 15 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation NFATC2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation, relocalization NFATC2 0.70
Publications: 3 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png dephosphorylation, relocalization NFATC2 0.68
Publications: 2 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png dephosphorylation, relocalization NFATC2 0.48
Publications: 2 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png binding MEF2D 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png binding MEF2A 0.41
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates img/indirect-activation.png unknown NFATC2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation MYOF
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL6
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOG
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation NFATC2 0.24
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYOF 0.59
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates img/direct_inhibition.png phosphorylation NFATC2 0.06
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates img/indirect-activation.png transcriptional regulation IL4 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FST
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation NFATC2 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL4 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation, relocalization NFATC2
Publications: 3 Organism: Homo Sapiens
Tissue: Skeletal Muscle