| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| Calcineurin | NFATC2 | Ser274 | ASPQRSRsPSPQPSS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252328 |
| PPP3CB | NFATC2 | Ser274 | ASPQRSRsPSPQPSS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248375 |
| PPP3CA | NFATC2 | Ser274 | ASPQRSRsPSPQPSS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248689 |
| PPP3CC | NFATC2 | Ser274 | ASPQRSRsPSPQPSS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-248520 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer274 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252328 |
| PPP3CB | dephosphorylation down-regulates ⊣ | NFATC2 PSer274 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248375 |
| PPP3CA | dephosphorylation down-regulates ⊣ | NFATC2 PSer274 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248689 |
| PPP3CC | dephosphorylation down-regulates ⊣ | NFATC2 PSer274 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-248520 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252328 |
| PPP3CB | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248375 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248689 |
| PPP3CC | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-248520 |
