| Name | CAMK2B |
| ID | Q13554 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 14-272 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2B | ETS1 | Ser251 | GKLGGQDsFESIESY | phosphorylation down-regulates activity | 12475968 | SIGNOR-250684 |
| CAMK2B | ETS1 | Ser257 | DSFESIEsYDSCDRL | phosphorylation down-regulates activity | 12475968 | SIGNOR-250685 |
| CAMK2B | ETS1 | Ser282 | NSLQRVPsYDSFDSE | phosphorylation down-regulates activity | 12475968 | SIGNOR-250686 |
| CAMK2B | ETS1 | Ser285 | QRVPSYDsFDSEDYP | phosphorylation down-regulates activity | 12475968 | SIGNOR-250687 |
| CAMK2B | STMN1 | Ser16 | KELEKRAsGQAFELI | phosphorylation down-regulates | 9686569 | SIGNOR-59358 |
| CAMK2B | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation down-regulates | 24117889 | SIGNOR-202825 |
| CAMK2B | CTNNB1 | Thr332 | VNIMRTYtYEKLLWT | phosphorylation down-regulates | 24117889 | SIGNOR-202829 |
| CAMK2B | CTNNB1 | Thr472 | ICALRHLtSRHQEAE | phosphorylation down-regulates | 24117889 | SIGNOR-202833 |
| CAMK2B | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates | 17502367 | SIGNOR-154771 |
| CAMK2B | GSK3A | Ser21 | SGRARTSsFAEPGGG | phosphorylation down-regulates | 20841359 | SIGNOR-167962 |
| CAMK2B | PLCB3 | Ser537 | PSLEPQKsLGDEGLN | phosphorylation unknown | 11325525 | SIGNOR-250689 |
| CAMK2B | PRKAA1 | Thr183 | SDGEFLRtSCGSPNY | phosphorylation up-regulates | 15980064 | SIGNOR-138360 |
| CAMK2B | GRIN2B | Ser1303 | NKLRRQHsYDTFVDL | phosphorylation up-regulates activity | 8940188 | SIGNOR-250688 |
| CAMK2B | CAMK2B | Thr287 | SMMHRQEtVECLKKF | phosphorylation up-regulates activity | 2842767 | SIGNOR-250640 |
| CAMK2B | SCN5A | Ser516 | LSLTRGLsRTSMKPR | phosphorylation up-regulates activity | 33410863 | SIGNOR-275773 |
| CAMK2B | SCN5A | Ser571 | PWPLRRTsAQGQPSP | phosphorylation up-regulates activity | 33410863 | SIGNOR-275774 |
| CAMK2B | SCN5A | Thr594 | LHGKKNStVDCNGVV | phosphorylation up-regulates activity | 33410863 | SIGNOR-275775 |
| CAMK2B | RETREG1 | Ser151 | AQLWRSLsESWEVIN | phosphorylation up-regulates activity | 31930741 | SIGNOR-273554 |
| CAMK2B | CYLD | Ser362 | FYTLNGSsVDSQPQS | phosphorylation up-regulates | 24614225 | SIGNOR-25334 |
| CAMK2B | CYLD | Ser772 | LFKKIFPsLELNITD | phosphorylation up-regulates | 24614225 | SIGNOR-91403 |
| CAMK2B | CYLD | Ser418 | TTENRFHsLPFSLTK | phosphorylation up-regulates activity | 24614225 | SIGNOR-25329 |
| CAMK2B | GABBR1 | Ser868 | ITRGEWQsEAQDTMK | phosphorylation down-regulates quantity by destabilization | 37686242 | SIGNOR-277851 |
| CAMK2B | GABBR1 | Thr873 | WQSEAQDtMKTGSST | phosphorylation down-regulates quantity by destabilization | 37686242 | SIGNOR-277850 |
| CAMK2B | SCN8A | Ser561 | PFLSRHNsKSSIFSF | phosphorylation up-regulates activity | 32611770 | SIGNOR-275787 |
| CAMK2B | SCN8A | Ser641 | RRSVKRNsTVDCNGV | phosphorylation up-regulates activity | 32611770 | SIGNOR-275788 |
| CAMK2B | SCN8A | Thr642 | RSVKRNStVDCNGVV | phosphorylation up-regulates activity | 32611770 | SIGNOR-275789 |
| CAMK2B | AMPK | – | phosphorylation up-regulates | 15980064 | SIGNOR-217493 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2B | phosphorylation up-regulates → | ETS1 PSer251 | phosphorylation down-regulates ⊣ | ETS1 | 12475968 | SIGNOR-250684 |
| CAMK2B | phosphorylation up-regulates → | ETS1 PSer257 | phosphorylation down-regulates ⊣ | ETS1 | 12475968 | SIGNOR-250685 |
| CAMK2B | phosphorylation up-regulates → | ETS1 PSer282 | phosphorylation down-regulates ⊣ | ETS1 | 12475968 | SIGNOR-250686 |
| CAMK2B | phosphorylation up-regulates → | ETS1 PSer285 | phosphorylation down-regulates ⊣ | ETS1 | 12475968 | SIGNOR-250687 |
| CAMK2B | phosphorylation up-regulates → | STMN1 PSer16 | phosphorylation down-regulates ⊣ | STMN1 | 9686569 | SIGNOR-59358 |
| CAMK2B | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation down-regulates ⊣ | CTNNB1 | 24117889 | SIGNOR-202825 |
| CAMK2B | phosphorylation up-regulates → | CTNNB1 PThr332 | phosphorylation down-regulates ⊣ | CTNNB1 | 24117889 | SIGNOR-202829 |
| CAMK2B | phosphorylation up-regulates → | CTNNB1 PThr472 | phosphorylation down-regulates ⊣ | CTNNB1 | 24117889 | SIGNOR-202833 |
| CAMK2B | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 17502367 | SIGNOR-154771 |
| CAMK2B | phosphorylation up-regulates → | GSK3A PSer21 | phosphorylation down-regulates ⊣ | GSK3A | 20841359 | SIGNOR-167962 |
| CAMK2B | phosphorylation up-regulates → | PLCB3 PSer537 | phosphorylation down-regulates ⊣ | PLCB3 | 11325525 | SIGNOR-250689 |
| CAMK2B | phosphorylation up-regulates → | PRKAA1 PThr183 | phosphorylation up-regulates → | PRKAA1 | 15980064 | SIGNOR-138360 |
| CAMK2B | phosphorylation up-regulates → | GRIN2B PSer1303 | phosphorylation up-regulates → | GRIN2B | 8940188 | SIGNOR-250688 |
| CAMK2B | phosphorylation up-regulates → | CAMK2B PThr287 | phosphorylation up-regulates → | CAMK2B | 2842767 | SIGNOR-250640 |
| CAMK2B | phosphorylation up-regulates → | SCN5A PSer516 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275773 |
| CAMK2B | phosphorylation up-regulates → | SCN5A PSer571 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275774 |
| CAMK2B | phosphorylation up-regulates → | SCN5A PThr594 | phosphorylation up-regulates → | SCN5A | 33410863 | SIGNOR-275775 |
| CAMK2B | phosphorylation up-regulates → | RETREG1 PSer151 | phosphorylation up-regulates → | RETREG1 | 31930741 | SIGNOR-273554 |
| CAMK2B | phosphorylation up-regulates → | CYLD PSer362 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-25334 |
| CAMK2B | phosphorylation up-regulates → | CYLD PSer772 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-91403 |
| CAMK2B | phosphorylation up-regulates → | CYLD PSer418 | phosphorylation up-regulates → | CYLD | 24614225 | SIGNOR-25329 |
| CAMK2B | phosphorylation up-regulates → | GABBR1 PSer868 | phosphorylation down-regulates ⊣ | GABBR1 | 37686242 | SIGNOR-277851 |
| CAMK2B | phosphorylation up-regulates → | GABBR1 PThr873 | phosphorylation down-regulates ⊣ | GABBR1 | 37686242 | SIGNOR-277850 |
| CAMK2B | phosphorylation up-regulates → | SCN8A PSer561 | phosphorylation up-regulates → | SCN8A | 32611770 | SIGNOR-275787 |
| CAMK2B | phosphorylation up-regulates → | SCN8A PSer641 | phosphorylation up-regulates → | SCN8A | 32611770 | SIGNOR-275788 |
| CAMK2B | phosphorylation up-regulates → | SCN8A PThr642 | phosphorylation up-regulates → | SCN8A | 32611770 | SIGNOR-275789 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK2B | phosphorylation → down-regulates activity | ETS1 | SIGNOR-250684 |
| CAMK2B | phosphorylation → down-regulates activity | ETS1 | SIGNOR-250685 |
| CAMK2B | phosphorylation → down-regulates activity | ETS1 | SIGNOR-250686 |
| CAMK2B | phosphorylation → down-regulates activity | ETS1 | SIGNOR-250687 |
| CAMK2B | phosphorylation![]() down-regulates | STMN1 | SIGNOR-59358 |
| CAMK2B | phosphorylation![]() down-regulates | CTNNB1 | SIGNOR-202825 |
| CAMK2B | phosphorylation![]() down-regulates | CTNNB1 | SIGNOR-202829 |
| CAMK2B | phosphorylation![]() down-regulates | CTNNB1 | SIGNOR-202833 |
| CAMK2B | phosphorylation → up-regulates | STAT1 | SIGNOR-154771 |
| CAMK2B | phosphorylation![]() down-regulates | GSK3A | SIGNOR-167962 |
| CAMK2B | phosphorylation → unknown | PLCB3 | SIGNOR-250689 |
| CAMK2B | phosphorylation → up-regulates | PRKAA1 | SIGNOR-138360 |
| CAMK2B | phosphorylation → up-regulates activity | GRIN2B | SIGNOR-250688 |
| CAMK2B | phosphorylation → up-regulates activity | CAMK2B | SIGNOR-250640 |
| CAMK2B | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275773 |
| CAMK2B | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275774 |
| CAMK2B | phosphorylation → up-regulates activity | SCN5A | SIGNOR-275775 |
| CAMK2B | phosphorylation → up-regulates activity | RETREG1 | SIGNOR-273554 |
| CAMK2B | phosphorylation → up-regulates | CYLD | SIGNOR-25334 |
| CAMK2B | phosphorylation → up-regulates | CYLD | SIGNOR-91403 |
| CAMK2B | phosphorylation → up-regulates activity | CYLD | SIGNOR-25329 |
| CAMK2B | phosphorylation![]() down-regulates quantity by destabilization | GABBR1 | SIGNOR-277851 |
| CAMK2B | phosphorylation![]() down-regulates quantity by destabilization | GABBR1 | SIGNOR-277850 |
| CAMK2B | phosphorylation → up-regulates activity | SCN8A | SIGNOR-275787 |
| CAMK2B | phosphorylation → up-regulates activity | SCN8A | SIGNOR-275788 |
| CAMK2B | phosphorylation → up-regulates activity | SCN8A | SIGNOR-275789 |
| CAMK2B | phosphorylation → up-regulates | AMPK | SIGNOR-217493 |