Summary

Name CAMK2B
Full Name Calcium/calmodulin-dependent protein kinase type II subunit beta
Synonyms CaM kinase II subunit beta, CaMK-II subunit beta | CAM2, CAMK2, CAMKB
Primary ID Q13554
Links - -
Type protein
Relations 18
Function Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.69
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation STMN1 0.60
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3A 0.73
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ETS1 0.38
Publications: 4
+ up-regulates img/direct-activation.png phosphorylation CYLD
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PLCB3 0.76
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation CTNNB1 0.07
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.29
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAA1 0.47
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CAMK2B
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation AMPK
Publications: 1 Organism: Homo Sapiens