| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHUK | IRF5 | – | phosphorylation down-regulates activity | 19786094 | SIGNOR-278293 | |
| LYN | IRF5 | Tyr313 | PSDKQRFyTNQLLDV | phosphorylation down-regulates activity | 27521268 | SIGNOR-277247 |
| LYN | IRF5 | Tyr313 | PSDKQRFyTNQLLDV | phosphorylation down-regulates activity | 30515152 | SIGNOR-279206 |
| IKBKB | IRF5 | Ser446 | DSIRLQIsNPDLKDR | phosphorylation up-regulates activity | 25326420 | SIGNOR-279466 |
| LYN | IRF5 | Tyr335 | QLQGQDLyAIRLCQC | phosphorylation down-regulates activity | 30515152 | SIGNOR-279207 |
| RIPK2 | IRF5 | Ser446 | DSIRLQIsNPDLKDR | phosphorylation up-regulates | 22412986 | SIGNOR-196524 |
| TBK1 | IRF5 | Ser293 | VELFGPIsLEQVRFP | phosphorylation up-regulates | 22412986 | SIGNOR-196532 |
| RIPK2 | IRF5 | Ser435 | EMFSGELsWSADSIR | phosphorylation up-regulates | 22412986 | SIGNOR-196520 |
| TBK1 | IRF5 | Ser158 | QRMLPSLsLTEDVKW | phosphorylation up-regulates | 22412986 | SIGNOR-196528 |
| LYN | IRF5 | Tyr335 | QLQGQDLyAIRLCQC | phosphorylation down-regulates activity | 27521268 | SIGNOR-277248 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LYN | phosphorylation up-regulates → | IRF5 PTyr313 | phosphorylation down-regulates ⊣ | IRF5 | 27521268 | SIGNOR-277247 |
| LYN | phosphorylation up-regulates → | IRF5 PTyr313 | phosphorylation down-regulates ⊣ | IRF5 | 30515152 | SIGNOR-279206 |
| IKBKB | phosphorylation up-regulates → | IRF5 PSer446 | phosphorylation up-regulates → | IRF5 | 25326420 | SIGNOR-279466 |
| LYN | phosphorylation up-regulates → | IRF5 PTyr335 | phosphorylation down-regulates ⊣ | IRF5 | 30515152 | SIGNOR-279207 |
| RIPK2 | phosphorylation up-regulates → | IRF5 PSer446 | phosphorylation up-regulates → | IRF5 | 22412986 | SIGNOR-196524 |
| TBK1 | phosphorylation up-regulates → | IRF5 PSer293 | phosphorylation up-regulates → | IRF5 | 22412986 | SIGNOR-196532 |
| RIPK2 | phosphorylation up-regulates → | IRF5 PSer435 | phosphorylation up-regulates → | IRF5 | 22412986 | SIGNOR-196520 |
| TBK1 | phosphorylation up-regulates → | IRF5 PSer158 | phosphorylation up-regulates → | IRF5 | 22412986 | SIGNOR-196528 |
| LYN | phosphorylation up-regulates → | IRF5 PTyr335 | phosphorylation down-regulates ⊣ | IRF5 | 27521268 | SIGNOR-277248 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHUK | phosphorylation → down-regulates activity | IRF5 | SIGNOR-278293 |
| LYN | phosphorylation → down-regulates activity | IRF5 | SIGNOR-277247 |
| LYN | phosphorylation → down-regulates activity | IRF5 | SIGNOR-279206 |
| IKBKB | phosphorylation → up-regulates activity | IRF5 | SIGNOR-279466 |
| LYN | phosphorylation → down-regulates activity | IRF5 | SIGNOR-279207 |
| RIPK2 | phosphorylation → up-regulates | IRF5 | SIGNOR-196524 |
| TBK1 | phosphorylation → up-regulates | IRF5 | SIGNOR-196532 |
| RIPK2 | phosphorylation → up-regulates | IRF5 | SIGNOR-196520 |
| TBK1 | phosphorylation → up-regulates | IRF5 | SIGNOR-196528 |
| LYN | phosphorylation → down-regulates activity | IRF5 | SIGNOR-277248 |
