Summary

Name IRF5
Full Name Interferon regulatory factor 5
Synonyms IRF-5
Primary ID Q13568
Links - -
Type protein
Relations 12
Pathways Macrophage: IL10, Macrophage: IL1 beta transcriptional regulation, Macrophage: TNF alpha transcriptional regulation
Function Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation IRF5 0.563
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IRF5 0.312
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IRF5 0.294
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png M1_polarization 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation IL1B 0.299
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ down-regulates img/indirect_inhibition.png transcriptional regulation IL10 0.442
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TNF 0.468
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation IL10 0.442
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png IRF5 0.429
Publications: 1 Organism: Homo Sapiens