| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RIPK2 | IRF5 | Ser446 | DSIRLQIsNPDLKDR | phosphorylation up-regulates | 22412986 | SIGNOR-196524 |
| IKBKB | IRF5 | Ser446 | DSIRLQIsNPDLKDR | phosphorylation up-regulates activity | 25326420 | SIGNOR-279466 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RIPK2 | phosphorylation up-regulates → | IRF5 PSer446 | phosphorylation up-regulates → | IRF5 | 22412986 | SIGNOR-196524 |
| IKBKB | phosphorylation up-regulates → | IRF5 PSer446 | phosphorylation up-regulates → | IRF5 | 25326420 | SIGNOR-279466 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RIPK2 | phosphorylation → up-regulates | IRF5 | SIGNOR-196524 |
| IKBKB | phosphorylation → up-regulates activity | IRF5 | SIGNOR-279466 |
