| Name | STIM1 |
| ID | Q13586 |
| Role | substrate |
| Enzymatic Domains |
EF-hand 1 64-97 PubMed
EF-hand 2 102-126 PubMed |
View in ![]() |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | STIM1 | Ser668 | IGEETDSsPGRKKFP | phosphorylation down-regulates | 19881501 | SIGNOR-189017 |
| MAPK1 | STIM1 | Ser575 | LVEKLPDsPALAKKA | phosphorylation up-regulates | 22298426 | SIGNOR-192788 |
| PRKAG2 | STIM1 | Ser257 | GLHRAEQsLHDLQER | phosphorylation down-regulates activity | 31381180 | SIGNOR-277297 |
| FAM20C | STIM1 | Ser88 | GDVDVEEsDEFLRED | phosphorylation up-regulates activity | 30520731 | SIGNOR-279173 |
| PRKAB1 | STIM1 | Ser257 | GLHRAEQsLHDLQER | phosphorylation down-regulates activity | 31381180 | SIGNOR-277298 |
| PAK1 | STIM1 | – | phosphorylation up-regulates activity | 29780159 | SIGNOR-279244 | |
| PRKAA1 | STIM1 | Ser257 | GLHRAEQsLHDLQER | phosphorylation down-regulates activity | 31381180 | SIGNOR-277299 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | STIM1 PSer668 | phosphorylation down-regulates ⊣ | STIM1 | 19881501 | SIGNOR-189017 |
| MAPK1 | phosphorylation up-regulates → | STIM1 PSer575 | phosphorylation up-regulates → | STIM1 | 22298426 | SIGNOR-192788 |
| PRKAG2 | phosphorylation up-regulates → | STIM1 PSer257 | phosphorylation down-regulates ⊣ | STIM1 | 31381180 | SIGNOR-277297 |
| FAM20C | phosphorylation up-regulates → | STIM1 PSer88 | phosphorylation up-regulates → | STIM1 | 30520731 | SIGNOR-279173 |
| PRKAB1 | phosphorylation up-regulates → | STIM1 PSer257 | phosphorylation down-regulates ⊣ | STIM1 | 31381180 | SIGNOR-277298 |
| PRKAA1 | phosphorylation up-regulates → | STIM1 PSer257 | phosphorylation down-regulates ⊣ | STIM1 | 31381180 | SIGNOR-277299 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation![]() down-regulates | STIM1 | SIGNOR-189017 |
| MAPK1 | phosphorylation → up-regulates | STIM1 | SIGNOR-192788 |
| PRKAG2 | phosphorylation → down-regulates activity | STIM1 | SIGNOR-277297 |
| FAM20C | phosphorylation → up-regulates activity | STIM1 | SIGNOR-279173 |
| PRKAB1 | phosphorylation → down-regulates activity | STIM1 | SIGNOR-277298 |
| PAK1 | phosphorylation → up-regulates activity | STIM1 | SIGNOR-279244 |
| PRKAA1 | phosphorylation → down-regulates activity | STIM1 | SIGNOR-277299 |