Summary

Name STIM1
Full Name Stromal interaction molecule 1
Synonyms STIM1_HUMAN | GOK
Primary ID Q13586
Links - -
Type protein
Relations 7
Function Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555, PubMed:28219928). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671). Activated following interaction with STIMATE, leading to promote STIM1 conformational switch (PubMed:26322679).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PRKAA1down-regulates activity img/direct_inhibition.png phosphorylation STIM1 0.2
Publications: 1 Organism: Mus Musculus
+ PRKAG2down-regulates activity img/direct_inhibition.png phosphorylation STIM1 0.2
Publications: 1 Organism: Mus Musculus
+ PRKAB1down-regulates activity img/direct_inhibition.png phosphorylation STIM1 0.2
Publications: 1 Organism: Mus Musculus
+ MAPK1up-regulates img/direct-activation.png phosphorylation STIM1 0.35
Publications: 1 Organism: Homo Sapiens
+ CDK1down-regulates img/direct_inhibition.png phosphorylation STIM1 0.345
Publications: 1 Organism: Homo Sapiens
+ FAM20Cup-regulates activity img/direct-activation.png phosphorylation STIM1 0.2
Publications: 1 Organism: Homo Sapiens
+ PAK1up-regulates activity img/direct-activation.png phosphorylation STIM1 0.354
Publications: 1 Organism: Homo Sapiens