| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA1 | STIM1 | Ser257 | GLHRAEQsLHDLQER | phosphorylation down-regulates activity | 31381180 | SIGNOR-277299 |
| PRKAG2 | STIM1 | Ser257 | GLHRAEQsLHDLQER | phosphorylation down-regulates activity | 31381180 | SIGNOR-277297 |
| PRKAB1 | STIM1 | Ser257 | GLHRAEQsLHDLQER | phosphorylation down-regulates activity | 31381180 | SIGNOR-277298 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA1 | phosphorylation up-regulates → | STIM1 PSer257 | phosphorylation down-regulates ⊣ | STIM1 | 31381180 | SIGNOR-277299 |
| PRKAG2 | phosphorylation up-regulates → | STIM1 PSer257 | phosphorylation down-regulates ⊣ | STIM1 | 31381180 | SIGNOR-277297 |
| PRKAB1 | phosphorylation up-regulates → | STIM1 PSer257 | phosphorylation down-regulates ⊣ | STIM1 | 31381180 | SIGNOR-277298 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKAA1 | phosphorylation → down-regulates activity | STIM1 | SIGNOR-277299 |
| PRKAG2 | phosphorylation → down-regulates activity | STIM1 | SIGNOR-277297 |
| PRKAB1 | phosphorylation → down-regulates activity | STIM1 | SIGNOR-277298 |