| Name | DYRK1A |
| ID | Q13627 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 159-479 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | DYRK1A | Tyr319 | CQLGQRIyQYIQSRF | phosphorylation up-regulates | 10910078 | SIGNOR-79760 |
| DYRK1A | DYRK1A | Tyr321 | LGQRIYQyIQSRFYR | phosphorylation up-regulates | 10910078 | SIGNOR-79764 |
| PPM1B | DYRK1A | Ser258 | NTNFRGVsLNLTRKF | dephosphorylation down-regulates activity | 33380426 | SIGNOR-277108 |
| DYRK1A | DYRK1A | Ser529 | SNSGRARsDPTHQHR | phosphorylation up-regulates activity | 17229891 | SIGNOR-251090 |
| DYRK1A | DYRK1A | Tyr321 | LGQRIYQyIQSRFYR | phosphorylation up-regulates activity | 11672423 | SIGNOR-111145 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | phosphorylation up-regulates → | DYRK1A PTyr319 | phosphorylation up-regulates → | DYRK1A | 10910078 | SIGNOR-79760 |
| DYRK1A | phosphorylation up-regulates → | DYRK1A PTyr321 | phosphorylation up-regulates → | DYRK1A | 10910078 | SIGNOR-79764 |
| PPM1B | dephosphorylation down-regulates ⊣ | DYRK1A PSer258 | dephosphorylation up-regulates → | DYRK1A | 33380426 | SIGNOR-277108 |
| DYRK1A | phosphorylation up-regulates → | DYRK1A PSer529 | phosphorylation up-regulates → | DYRK1A | 17229891 | SIGNOR-251090 |
| DYRK1A | phosphorylation up-regulates → | DYRK1A PTyr321 | phosphorylation up-regulates → | DYRK1A | 11672423 | SIGNOR-111145 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK1A | phosphorylation → up-regulates | DYRK1A | SIGNOR-79760 |
| DYRK1A | phosphorylation → up-regulates | DYRK1A | SIGNOR-79764 |
| PPM1B | dephosphorylation → down-regulates activity | DYRK1A | SIGNOR-277108 |
| DYRK1A | phosphorylation → up-regulates activity | DYRK1A | SIGNOR-251090 |
| DYRK1A | phosphorylation → up-regulates activity | DYRK1A | SIGNOR-111145 |