Summary

Name DYRK1A
Full Name Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Synonyms Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB | DYRK, MNB, MNBH
Primary ID Q13627
Links - -
Type protein
Relations 56
Function Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation CDKN1B 0.334
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TP53 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RCAN1 0.567
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SRSF1 0.392
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png phosphorylation MEF2D 0.413
Publications: 2 Organism: Homo Sapiens, In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation DYRK1A 0.237
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NFATC1 0.433
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation AMPH 0.398
Publications: 7 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png phosphorylation LIN52 0.679
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation AMPH 0.398
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO 0.51
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO1 0.51
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.361
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CCNL2 0.576
Publications: 3 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.51
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.361
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation PLK2 0.313
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAPT 0.431
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DYRK1A 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GYS1 0.268
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation DNM1 0.418
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation SNCA 0.565
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CCND1 0.399
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SF3B1 0.504
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SIRT1 0.543
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SPRY2 0.306
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DYRK1A 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GLI1 0.517
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SRSF2 0.411
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH1 0.399
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation FOXO1 0.51
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH 0.399
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates activity img/direct-activation.png binding DYRK1A 0.714
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation FOXO6 0.306
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO4 0.317
Publications: 1 Organism: Homo Sapiens