| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKD1 | CACNA1C | Ser1981 | ASLGRRAsFHLECLK | phosphorylation up-regulates | 22100296 | SIGNOR-177481 |
| SRC | CACNA1C | Tyr2217 | ELQDSRVyVSSL | phosphorylation up-regulates activity | 17942635 | SIGNOR-276081 |
| PRKACA | CACNA1C | Ser1897 | LLRKANPsRCHSRES | phosphorylation up-regulates activity | 28119464 | SIGNOR-251709 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKD1 | phosphorylation up-regulates → | CACNA1C PSer1981 | phosphorylation up-regulates → | CACNA1C | 22100296 | SIGNOR-177481 |
| SRC | phosphorylation up-regulates → | CACNA1C PTyr2217 | phosphorylation up-regulates → | CACNA1C | 17942635 | SIGNOR-276081 |
| PRKACA | phosphorylation up-regulates → | CACNA1C PSer1897 | phosphorylation up-regulates → | CACNA1C | 28119464 | SIGNOR-251709 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKD1 | phosphorylation → up-regulates | CACNA1C | SIGNOR-177481 |
| SRC | phosphorylation → up-regulates activity | CACNA1C | SIGNOR-276081 |
| PRKACA | phosphorylation → up-regulates activity | CACNA1C | SIGNOR-251709 |
