Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAPK14	RUNX2	–		phosphorylation up-regulates activity	20551513	SIGNOR-255777
MAPK3	RUNX2	Ser294 View in OncoXplorer	DPRQAQSsPPWSYDQ	phosphorylation up-regulates	19801668	SIGNOR-188343
DUSP1	RUNX2	Ser118	AELVRTDsPNFLCSV	dephosphorylation up-regulates activity	27031422	SIGNOR-277143
GSK3B	RUNX2	–		phosphorylation down-regulates activity	17786208	SIGNOR-279051
PPM1D	RUNX2	–		dephosphorylation up-regulates activity	23907458	SIGNOR-277110
AKT1	RUNX2	–		phosphorylation down-regulates activity	23389849	SIGNOR-280176
CDK1	RUNX2	Ser465	MVPGGDRsPSRMLPP	phosphorylation up-regulates	16407259	SIGNOR-143586
MAPK3	RUNX2	Ser312	SYLSQMTsPSIHSTT	phosphorylation up-regulates	19801668	SIGNOR-188347

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAPK3	phosphorylation up-regulates →	RUNX2 PSer294	phosphorylation up-regulates →	RUNX2	19801668	SIGNOR-188343
DUSP1	dephosphorylation down-regulates ⊣	RUNX2 PSer118	dephosphorylation down-regulates ⊣	RUNX2	27031422	SIGNOR-277143
CDK1	phosphorylation up-regulates →	RUNX2 PSer465	phosphorylation up-regulates →	RUNX2	16407259	SIGNOR-143586
MAPK3	phosphorylation up-regulates →	RUNX2 PSer312	phosphorylation up-regulates →	RUNX2	19801668	SIGNOR-188347

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAPK14	phosphorylation → up-regulates activity	RUNX2	SIGNOR-255777
MAPK3	phosphorylation → up-regulates	RUNX2	SIGNOR-188343
DUSP1	dephosphorylation → up-regulates activity	RUNX2	SIGNOR-277143
GSK3B	phosphorylation → down-regulates activity	RUNX2	SIGNOR-279051
PPM1D	dephosphorylation → up-regulates activity	RUNX2	SIGNOR-277110
AKT1	phosphorylation → down-regulates activity	RUNX2	SIGNOR-280176
CDK1	phosphorylation → up-regulates	RUNX2	SIGNOR-143586
MAPK3	phosphorylation → up-regulates	RUNX2	SIGNOR-188347