Summary

Name RUNX2
Full Name Runt-related transcription factor 2
Synonyms Acute myeloid leukemia 3 protein, Core-binding factor subunit alpha-1, CBF-alpha-1, Oncogene AML-3, Osteoblast-specific transcription factor 2, OSF-2, Polyomavirus enhancer-binding protein 2 alpha A subunit, PEA2-alpha A, PEBP2-alpha A, SL3-3 enhancer factor 1 alpha A subunit, SL3/AKV core-binding factor alpha A subunit | AML3, CBFA1, OSF2, PEBP2A
Primary ID Q13950
Links - -
Type protein
Relations 66
Pathways TGFbeta Signaling
Function Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28738062, PubMed:28703881). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation RUNX2 0.3
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RUNX2 0.44
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RUNX2 0.34
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP13 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RUNX2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RUNX2 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ up-regulates img/direct-activation.png binding RUNX2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ELANE 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CREBBP 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RUNX2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RUNX2 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COL2A1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png deacetylation RUNX2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation RUNX2 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png transcriptional regulation RUNX2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png binding RUNX2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ENPP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BGLAP 0.28
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates img/indirect-activation.png RUNX2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation RUNX2 0.23
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation SP7 0.28
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding RUNX2 0.23
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RUNX2 0.3
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BMP2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding RUNX2 0.48
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RUNX2 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png acetylation RUNX2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png deacetylation RUNX2 0.31
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination RUNX2 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RUNX2 0.14
Publications: 1 Organism: Mus Musculus
Pathways:TGFbeta Signaling
+ down-regulates img/direct_inhibition.png binding NOTCH1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png deacetylation, binding RUNX2 0.31
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
+ up-regulates quantity img/direct-activation.png transcriptional regulation SPP1 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png deacetylation RUNX2 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RUNX2 0.14
Publications: 1 Organism: Mus Musculus
Pathways:TGFbeta Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SNAI2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation VEGFC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MMP2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Osteoblast Differentiation 0.31
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding RUNX2/EP300 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png binding RUNX2 0.31
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COL1A1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COL1A2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RUNX2 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ALPL 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RUNX2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SPP1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TNFSF11 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RUNX2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RUNX2 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RUNX2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RUNX2 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SNAI3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TWIST1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation VEGFA 0.14
Publications: 1 Organism: Homo Sapiens