| Name | RASGRF1 |
| ID | Q13972 |
| Role | substrate |
| Enzymatic Domains |
PH 1 22-129 PROSITE-ProRule
IQ 204-229 PROSITE-ProRule
DH 240-426 PROSITE-ProRule
PH 2 467-584 PROSITE-ProRule
N-terminal Ras-GEF 644-761 PROSITE-ProRule
Ras-GEF 1038-1270 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | RASGRF1 | – | phosphorylation down-regulates activity | 24597981 | SIGNOR-280133 | |
| PRKACA | RASGRF1 | Ser927 | KEKYRRMsLASAGFP | phosphorylation up-regulates | 10601308 | SIGNOR-73202 |
| CHEK2 | RASGRF1 | Ser287 | PITHDDVsSIFLNSE | phosphorylation down-regulates | 17110335 | SIGNOR-150843 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | RASGRF1 PSer927 | phosphorylation up-regulates → | RASGRF1 | 10601308 | SIGNOR-73202 |
| CHEK2 | phosphorylation up-regulates → | RASGRF1 PSer287 | phosphorylation down-regulates ⊣ | RASGRF1 | 17110335 | SIGNOR-150843 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → down-regulates activity | RASGRF1 | SIGNOR-280133 |
| PRKACA | phosphorylation → up-regulates | RASGRF1 | SIGNOR-73202 |
| CHEK2 | phosphorylation down-regulates | RASGRF1 | SIGNOR-150843 |