| Name | PRKG1 |
| ID | Q13976 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 360-619 PROSITE-ProRule
AGC-kinase C-terminal 620-671 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG1 | SEPTIN3 | Ser91 | SQVSRKAsSWNREEK | phosphorylation up-regulates activity | 15107017 | SIGNOR-263183 |
| PRKG1 | LASP1 | Ser146 | MEPERRDsQDGSSYR | phosphorylation down-regulates activity | 12571245 | SIGNOR-97946 |
| PRKG1 | GSK3B | – | phosphorylation down-regulates activity | 22131966 | SIGNOR-280094 | |
| PRKG1 | GTF2I | Ser412 | GIPFRRPsTYGIPRL | phosphorylation up-regulates | 12082086 | SIGNOR-89849 |
| PRKG1 | GABRR1 | Ser443 | PQRKSQRsSYVSMRI | phosphorylation unknown | 12175859 | SIGNOR-262756 |
| PRKG1 | FHOD1 | Ser1131 | AARERKRsRGNRKSL | phosphorylation up-regulates | 15051728 | SIGNOR-123646 |
| PRKG1 | TRPC3 | – | phosphorylation down-regulates | 16331690 | SIGNOR-142964 | |
| PRKG1 | CFTR | Ser795 | TASTRKVsLAPQANL | phosphorylation up-regulates | 1377674 | SIGNOR-18249 |
| PRKG1 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation unknown | 11175347 | SIGNOR-249076 |
| PRKG1 | TRPC6 | Ser322 | KNDYKKLsMQCKDFV | phosphorylation down-regulates activity | 19961855 | SIGNOR-276271 |
| PRKG1 | CFTR | Ser795 | TASTRKVsLAPQANL | phosphorylation up-regulates | 10581361 | SIGNOR-72724 |
| PRKG1 | GABRR1 | Ser444 | QRKSQRSsYVSMRID | phosphorylation unknown | 12175859 | SIGNOR-262757 |
| PRKG1 | PLN | Ser16 | RSAIRRAsTIEMPQQ | phosphorylation up-regulates activity | 22199120 | SIGNOR-279269 |
| PRKG1 | SRF | Thr159 | DNKLRRYtTFSKRKT | phosphorylation up-regulates | 12809504 | SIGNOR-188185 |
| PRKG1 | HRH1 | Ser398 | WKRLRSHsRQYVSGL | phosphorylation down-regulates | 10101032 | SIGNOR-66019 |
| PRKG1 | RGS2 | Ser64 | KPKTGKKsKQQAFIK | phosphorylation up-regulates activity | 14608379 | SIGNOR-249241 |
| PRKG1 | CFTR | Ser813 | DIYSRRLsQETGLEI | phosphorylation up-regulates | 10581361 | SIGNOR-72728 |
| PRKG1 | GKAP1 | Ser106 | SNPVQKDsREENWQE | phosphorylation unknown | 10671526 | SIGNOR-249037 |
| PRKG1 | PRKAR1A | Ser101 | RRRRGAIsAEVYTEE | phosphorylation up-regulates activity | 29378851 | SIGNOR-277383 |
| PRKG1 | CFTR | Ser660 | FSAERRNsILTETLH | phosphorylation up-regulates | 1377674 | SIGNOR-18237 |
| PRKG1 | TRPC3 | Thr11 | SPSLRRMtVMREKGR | phosphorylation down-regulates | 16331690 | SIGNOR-142957 |
| PRKG1 | RGS18 | Ser216 | PTNLRRRsRSFTCNE | phosphorylation up-regulates activity | 24244663 | SIGNOR-273785 |
| PRKG1 | HSPB1 | Thr143 | RCFTRKYtLPPGVDP | phosphorylation down-regulates | 19593530 | SIGNOR-186792 |
| PRKG1 | TNNI3 | Ser24 | APIRRRSsNYRAYAT | phosphorylation up-regulates activity | 15769444 | SIGNOR-134644 |
| PRKG1 | TRPC3 | Ser251 | KNDYRKLsMQCKDFV | phosphorylation down-regulates | 16331690 | SIGNOR-142953 |
| PRKG1 | TNNI3 | Ser23 | PAPIRRRsSNYRAYA | phosphorylation up-regulates activity | 15769444 | SIGNOR-134640 |
| PRKG1 | PPP1R17 | Thr68 | KKPRRKDtPALHIPP | phosphorylation up-regulates | 10051666 | SIGNOR-263148 |
| PRKG1 | PLCB3 | Ser26 | VETLRRGsKFIKWDE | phosphorylation down-regulates activity | 11278298 | SIGNOR-249079 |
| PRKG1 | SF1 | Ser20 | PSKKRKRsRWNQDTM | phosphorylation down-regulates activity | 10449420 | SIGNOR-249018 |
| PRKG1 | HSPB1 | Ser78 | PAYSRALsRQLSSGV | phosphorylation down-regulates | 19593530 | SIGNOR-186784 |
| PRKG1 | FHOD1 | Ser1131 | AARERKRsRGNRKSL | phosphorylation up-regulates | 21106951 | SIGNOR-170094 |
| PRKG1 | CRIP2 | Ser104 | RAEERKAsGPPKGPS | phosphorylation unknown | 10681529 | SIGNOR-249038 |
| PRKG1 | ENAH | – | phosphorylation down-regulates activity | 15066263 | SIGNOR-268288 | |
| PRKG1 | PTS | Ser19 | AQVSRRIsFSASHRL | phosphorylation up-regulates | 10531334 | SIGNOR-71680 |
| PRKG1 | RYR1 | Ser2843 | KKKTRKIsQSAQTYD | phosphorylation unknown | 8380342 | SIGNOR-248918 |
| PRKG1 | PLCB3 | Ser1105 | LDRKRHNsISEAKMR | phosphorylation down-regulates activity | 11278298 | SIGNOR-249077 |
| PRKG1 | TRPC7 | Thr15 | KNMQRRHtTLREKGR | phosphorylation up-regulates activity | 21402151 | SIGNOR-263184 |
| PRKG1 | PRKG1 | Ser65 | TTRAQGIsAEPQTYR | phosphorylation up-regulates | 12080049 | SIGNOR-89839 |
| PRKG1 | CFTR | Ser700 | FGEKRKNsILNPINS | phosphorylation up-regulates activity | 1377674 | SIGNOR-248850 |
| PRKG1 | HRH1 | Ser398 | WKRLRSHsRQYVSGL | phosphorylation down-regulates | 15107581 | SIGNOR-124360 |
| PRKG1 | ITPR1 | Ser1764 | RPSGRREsLTSFGNG | phosphorylation unknown | 8132598 | SIGNOR-248916 |
| PRKG1 | EVL | – | phosphorylation down-regulates activity | 15066263 | SIGNOR-268290 | |
| PRKG1 | CFTR | Ser813 | DIYSRRLsQETGLEI | phosphorylation up-regulates | 1377674 | SIGNOR-18253 |
| PRKG1 | VASP | Ser157 | EHIERRVsNAGGPPA | phosphorylation unknown | 14679200 | SIGNOR-120347 |
| PRKG1 | VASP | Ser239 | GAKLRKVsKQEEASG | phosphorylation unknown | 14679200 | SIGNOR-120351 |
| PRKG1 | VASP | Thr278 | LARRRKAtQVGEKTP | phosphorylation down-regulates | 12576312 | SIGNOR-98139 |
| PRKG1 | RGS2 | Ser46 | KDWKTRLsYFLQNSS | phosphorylation up-regulates activity | 14608379 | SIGNOR-249240 |
| PRKG1 | CFTR | Ser660 | FSAERRNsILTETLH | phosphorylation up-regulates | 10581361 | SIGNOR-72712 |
| PRKG1 | PPP1R17 | Thr119 | KKPRRKDtPALHMSP | phosphorylation up-regulates | 10051666 | SIGNOR-263147 |
| PRKG1 | HSPB1 | Ser82 | RALSRQLsSGVSEIR | phosphorylation down-regulates | 19593530 | SIGNOR-186788 |
| PRKG1 | GTF2I | Ser784 | GVPFRRPsTFGIPRL | phosphorylation up-regulates | 12082086 | SIGNOR-89853 |
| PRKG1 | VASP | – | phosphorylation down-regulates activity | 15066263 | SIGNOR-268289 | |
| PRKG1 | TRPC3 | Ser251 | KNDYRKLsMQCKDFV | phosphorylation down-regulates | 14983059 | SIGNOR-122978 |
| PRKG1 | SLC6A4 | Thr276 | SIWKGVKtSGKVVWV | phosphorylation up-regulates | 17913921 | SIGNOR-158186 |
| PRKG1 | TRPC6 | Thr70 | RLAHRRQtVLREKGR | phosphorylation down-regulates activity | 19961855 | SIGNOR-276272 |
| PRKG1 | TRPC3 | Ser251 | KNDYRKLsMQCKDFV | phosphorylation down-regulates | 16331690 | SIGNOR-142961 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG1 | phosphorylation up-regulates → | SEPTIN3 PSer91 | phosphorylation up-regulates → | SEPTIN3 | 15107017 | SIGNOR-263183 |
| PRKG1 | phosphorylation up-regulates → | LASP1 PSer146 | phosphorylation down-regulates ⊣ | LASP1 | 12571245 | SIGNOR-97946 |
| PRKG1 | phosphorylation up-regulates → | GTF2I PSer412 | phosphorylation up-regulates → | GTF2I | 12082086 | SIGNOR-89849 |
| PRKG1 | phosphorylation up-regulates → | GABRR1 PSer443 | phosphorylation down-regulates ⊣ | GABRR1 | 12175859 | SIGNOR-262756 |
| PRKG1 | phosphorylation up-regulates → | FHOD1 PSer1131 | phosphorylation up-regulates → | FHOD1 | 15051728 | SIGNOR-123646 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer795 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-18249 |
| PRKG1 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation down-regulates ⊣ | CREB1 | 11175347 | SIGNOR-249076 |
| PRKG1 | phosphorylation up-regulates → | TRPC6 PSer322 | phosphorylation down-regulates ⊣ | TRPC6 | 19961855 | SIGNOR-276271 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer795 | phosphorylation up-regulates → | CFTR | 10581361 | SIGNOR-72724 |
| PRKG1 | phosphorylation up-regulates → | GABRR1 PSer444 | phosphorylation down-regulates ⊣ | GABRR1 | 12175859 | SIGNOR-262757 |
| PRKG1 | phosphorylation up-regulates → | PLN PSer16 | phosphorylation up-regulates → | PLN | 22199120 | SIGNOR-279269 |
| PRKG1 | phosphorylation up-regulates → | SRF PThr159 | phosphorylation up-regulates → | SRF | 12809504 | SIGNOR-188185 |
| PRKG1 | phosphorylation up-regulates → | HRH1 PSer398 | phosphorylation down-regulates ⊣ | HRH1 | 10101032 | SIGNOR-66019 |
| PRKG1 | phosphorylation up-regulates → | RGS2 PSer64 | phosphorylation up-regulates → | RGS2 | 14608379 | SIGNOR-249241 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer813 | phosphorylation up-regulates → | CFTR | 10581361 | SIGNOR-72728 |
| PRKG1 | phosphorylation up-regulates → | GKAP1 PSer106 | phosphorylation down-regulates ⊣ | GKAP1 | 10671526 | SIGNOR-249037 |
| PRKG1 | phosphorylation up-regulates → | PRKAR1A PSer101 | phosphorylation up-regulates → | PRKAR1A | 29378851 | SIGNOR-277383 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer660 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-18237 |
| PRKG1 | phosphorylation up-regulates → | TRPC3 PThr11 | phosphorylation down-regulates ⊣ | TRPC3 | 16331690 | SIGNOR-142957 |
| PRKG1 | phosphorylation up-regulates → | RGS18 PSer216 | phosphorylation up-regulates → | RGS18 | 24244663 | SIGNOR-273785 |
| PRKG1 | phosphorylation up-regulates → | HSPB1 PThr143 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186792 |
| PRKG1 | phosphorylation up-regulates → | TNNI3 PSer24 | phosphorylation up-regulates → | TNNI3 | 15769444 | SIGNOR-134644 |
| PRKG1 | phosphorylation up-regulates → | TRPC3 PSer251 | phosphorylation down-regulates ⊣ | TRPC3 | 16331690 | SIGNOR-142953 |
| PRKG1 | phosphorylation up-regulates → | TNNI3 PSer23 | phosphorylation up-regulates → | TNNI3 | 15769444 | SIGNOR-134640 |
| PRKG1 | phosphorylation up-regulates → | PPP1R17 PThr68 | phosphorylation up-regulates → | PPP1R17 | 10051666 | SIGNOR-263148 |
| PRKG1 | phosphorylation up-regulates → | PLCB3 PSer26 | phosphorylation down-regulates ⊣ | PLCB3 | 11278298 | SIGNOR-249079 |
| PRKG1 | phosphorylation up-regulates → | SF1 PSer20 | phosphorylation down-regulates ⊣ | SF1 | 10449420 | SIGNOR-249018 |
| PRKG1 | phosphorylation up-regulates → | HSPB1 PSer78 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186784 |
| PRKG1 | phosphorylation up-regulates → | FHOD1 PSer1131 | phosphorylation up-regulates → | FHOD1 | 21106951 | SIGNOR-170094 |
| PRKG1 | phosphorylation up-regulates → | CRIP2 PSer104 | phosphorylation down-regulates ⊣ | CRIP2 | 10681529 | SIGNOR-249038 |
| PRKG1 | phosphorylation up-regulates → | PTS PSer19 | phosphorylation up-regulates → | PTS | 10531334 | SIGNOR-71680 |
| PRKG1 | phosphorylation up-regulates → | RYR1 PSer2843 | phosphorylation down-regulates ⊣ | RYR1 | 8380342 | SIGNOR-248918 |
| PRKG1 | phosphorylation up-regulates → | PLCB3 PSer1105 | phosphorylation down-regulates ⊣ | PLCB3 | 11278298 | SIGNOR-249077 |
| PRKG1 | phosphorylation up-regulates → | TRPC7 PThr15 | phosphorylation up-regulates → | TRPC7 | 21402151 | SIGNOR-263184 |
| PRKG1 | phosphorylation up-regulates → | PRKG1 PSer65 | phosphorylation up-regulates → | PRKG1 | 12080049 | SIGNOR-89839 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer700 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-248850 |
| PRKG1 | phosphorylation up-regulates → | HRH1 PSer398 | phosphorylation down-regulates ⊣ | HRH1 | 15107581 | SIGNOR-124360 |
| PRKG1 | phosphorylation up-regulates → | ITPR1 PSer1764 | phosphorylation down-regulates ⊣ | ITPR1 | 8132598 | SIGNOR-248916 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer813 | phosphorylation up-regulates → | CFTR | 1377674 | SIGNOR-18253 |
| PRKG1 | phosphorylation up-regulates → | VASP PSer157 | phosphorylation down-regulates ⊣ | VASP | 14679200 | SIGNOR-120347 |
| PRKG1 | phosphorylation up-regulates → | VASP PSer239 | phosphorylation down-regulates ⊣ | VASP | 14679200 | SIGNOR-120351 |
| PRKG1 | phosphorylation up-regulates → | VASP PThr278 | phosphorylation down-regulates ⊣ | VASP | 12576312 | SIGNOR-98139 |
| PRKG1 | phosphorylation up-regulates → | RGS2 PSer46 | phosphorylation up-regulates → | RGS2 | 14608379 | SIGNOR-249240 |
| PRKG1 | phosphorylation up-regulates → | CFTR PSer660 | phosphorylation up-regulates → | CFTR | 10581361 | SIGNOR-72712 |
| PRKG1 | phosphorylation up-regulates → | PPP1R17 PThr119 | phosphorylation up-regulates → | PPP1R17 | 10051666 | SIGNOR-263147 |
| PRKG1 | phosphorylation up-regulates → | HSPB1 PSer82 | phosphorylation down-regulates ⊣ | HSPB1 | 19593530 | SIGNOR-186788 |
| PRKG1 | phosphorylation up-regulates → | GTF2I PSer784 | phosphorylation up-regulates → | GTF2I | 12082086 | SIGNOR-89853 |
| PRKG1 | phosphorylation up-regulates → | TRPC3 PSer251 | phosphorylation down-regulates ⊣ | TRPC3 | 14983059 | SIGNOR-122978 |
| PRKG1 | phosphorylation up-regulates → | SLC6A4 PThr276 | phosphorylation up-regulates → | SLC6A4 | 17913921 | SIGNOR-158186 |
| PRKG1 | phosphorylation up-regulates → | TRPC6 PThr70 | phosphorylation down-regulates ⊣ | TRPC6 | 19961855 | SIGNOR-276272 |
| PRKG1 | phosphorylation up-regulates → | TRPC3 PSer251 | phosphorylation down-regulates ⊣ | TRPC3 | 16331690 | SIGNOR-142961 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKG1 | phosphorylation → up-regulates activity | SEPTIN3 | SIGNOR-263183 |
| PRKG1 | phosphorylation → down-regulates activity | LASP1 | SIGNOR-97946 |
| PRKG1 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-280094 |
| PRKG1 | phosphorylation → up-regulates | GTF2I | SIGNOR-89849 |
| PRKG1 | phosphorylation → unknown | GABRR1 | SIGNOR-262756 |
| PRKG1 | phosphorylation → up-regulates | FHOD1 | SIGNOR-123646 |
| PRKG1 | phosphorylation down-regulates | TRPC3 | SIGNOR-142964 |
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-18249 |
| PRKG1 | phosphorylation → unknown | CREB1 | SIGNOR-249076 |
| PRKG1 | phosphorylation → down-regulates activity | TRPC6 | SIGNOR-276271 |
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-72724 |
| PRKG1 | phosphorylation → unknown | GABRR1 | SIGNOR-262757 |
| PRKG1 | phosphorylation → up-regulates activity | PLN | SIGNOR-279269 |
| PRKG1 | phosphorylation → up-regulates | SRF | SIGNOR-188185 |
| PRKG1 | phosphorylation down-regulates | HRH1 | SIGNOR-66019 |
| PRKG1 | phosphorylation → up-regulates activity | RGS2 | SIGNOR-249241 |
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-72728 |
| PRKG1 | phosphorylation → unknown | GKAP1 | SIGNOR-249037 |
| PRKG1 | phosphorylation → up-regulates activity | PRKAR1A | SIGNOR-277383 |
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-18237 |
| PRKG1 | phosphorylation down-regulates | TRPC3 | SIGNOR-142957 |
| PRKG1 | phosphorylation → up-regulates activity | RGS18 | SIGNOR-273785 |
| PRKG1 | phosphorylation down-regulates | HSPB1 | SIGNOR-186792 |
| PRKG1 | phosphorylation → up-regulates activity | TNNI3 | SIGNOR-134644 |
| PRKG1 | phosphorylation down-regulates | TRPC3 | SIGNOR-142953 |
| PRKG1 | phosphorylation → up-regulates activity | TNNI3 | SIGNOR-134640 |
| PRKG1 | phosphorylation → up-regulates | PPP1R17 | SIGNOR-263148 |
| PRKG1 | phosphorylation → down-regulates activity | PLCB3 | SIGNOR-249079 |
| PRKG1 | phosphorylation → down-regulates activity | SF1 | SIGNOR-249018 |
| PRKG1 | phosphorylation down-regulates | HSPB1 | SIGNOR-186784 |
| PRKG1 | phosphorylation → up-regulates | FHOD1 | SIGNOR-170094 |
| PRKG1 | phosphorylation → unknown | CRIP2 | SIGNOR-249038 |
| PRKG1 | phosphorylation → down-regulates activity | ENAH | SIGNOR-268288 |
| PRKG1 | phosphorylation → up-regulates | PTS | SIGNOR-71680 |
| PRKG1 | phosphorylation → unknown | RYR1 | SIGNOR-248918 |
| PRKG1 | phosphorylation → down-regulates activity | PLCB3 | SIGNOR-249077 |
| PRKG1 | phosphorylation → up-regulates activity | TRPC7 | SIGNOR-263184 |
| PRKG1 | phosphorylation → up-regulates | PRKG1 | SIGNOR-89839 |
| PRKG1 | phosphorylation → up-regulates activity | CFTR | SIGNOR-248850 |
| PRKG1 | phosphorylation down-regulates | HRH1 | SIGNOR-124360 |
| PRKG1 | phosphorylation → unknown | ITPR1 | SIGNOR-248916 |
| PRKG1 | phosphorylation → down-regulates activity | EVL | SIGNOR-268290 |
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-18253 |
| PRKG1 | phosphorylation → unknown | VASP | SIGNOR-120347 |
| PRKG1 | phosphorylation → unknown | VASP | SIGNOR-120351 |
| PRKG1 | phosphorylation down-regulates | VASP | SIGNOR-98139 |
| PRKG1 | phosphorylation → up-regulates activity | RGS2 | SIGNOR-249240 |
| PRKG1 | phosphorylation → up-regulates | CFTR | SIGNOR-72712 |
| PRKG1 | phosphorylation → up-regulates | PPP1R17 | SIGNOR-263147 |
| PRKG1 | phosphorylation down-regulates | HSPB1 | SIGNOR-186788 |
| PRKG1 | phosphorylation → up-regulates | GTF2I | SIGNOR-89853 |
| PRKG1 | phosphorylation → down-regulates activity | VASP | SIGNOR-268289 |
| PRKG1 | phosphorylation down-regulates | TRPC3 | SIGNOR-122978 |
| PRKG1 | phosphorylation → up-regulates | SLC6A4 | SIGNOR-158186 |
| PRKG1 | phosphorylation → down-regulates activity | TRPC6 | SIGNOR-276272 |
| PRKG1 | phosphorylation down-regulates | TRPC3 | SIGNOR-142961 |