Summary

Name PRKG1
Full Name cGMP-dependent protein kinase 1
Synonyms cGK 1, cGK1, cGMP-dependent protein kinase I, cGKI | PRKG1B, PRKGR1A, PRKGR1B
Primary ID Q13976
Links - -
Type protein
Relations 46
Function Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation CRIP2 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation GKAP1 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation PLCB3 0.14
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation FHOD1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ img/unknown.png phosphorylation CREB1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation LASP1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation VASP 0.37
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ITPR1 0.4
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation PTS 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png phosphorylation SF1 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation TNNI3 0.14
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/direct_inhibition.png phosphorylation TRPC3 0.2
Publications: 4 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RYR1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation HRH1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png phosphorylation GTF2I 0.31
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png phosphorylation RGS2 0.31
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PRKG1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CFTR 0.2
Publications: 10 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CFTR 0.2
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TRPC3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SRF 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates img/direct-activation.png phosphorylation SLC6A4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKG1 0.14
Publications: 1 Organism: Homo Sapiens