Summary

Name PRKG1
Full Name cGMP-dependent protein kinase 1
Synonyms cGK 1, cGK1, cGMP-dependent protein kinase I, cGKI | PRKG1B, PRKGR1A, PRKGR1B
Primary ID Q13976
Links - -
Type protein
Relations 55
Pathways Axon guidance
Function Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm and nociception. Smooth muscle relaxation is mediated through lowering of intracellular free calcium, by desensitization of contractile proteins to calcium, and by decrease in the contractile state of smooth muscle or in platelet activation. Regulates intracellular calcium levels via several pathways

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PRKAR1A 0.234
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CRIP2 0.452
Publications: 1 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation GKAP1 0.626
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png phosphorylation PLCB3 0.537
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation FHOD1 0.355
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ img/unknown.png phosphorylation CREB1 0.644
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation LASP1 0.36
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation VASP 0.735
Publications: 2 Organism: Homo Sapiens
Pathways:Axon guidance
+ img/unknown.png phosphorylation ITPR1 0.462
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation PTS 0.257
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png phosphorylation SF1 0.44
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation RGS18 0.333
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TNNI3 0.359
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TRPC3 0.409
Publications: 4 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RYR1 0.391
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation TRPC6 0.489
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation HRH1 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png phosphorylation GTF2I 0.568
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ img/unknown.png phosphorylation GABRR1 0.318
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation RGS2 0.679
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PRKG1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates img/direct-activation.png phosphorylation CFTR 0.508
Publications: 6 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CFTR 0.508
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.274
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SEPTIN3 0.2
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation TRPC3 (isoform 3) 0.409
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PPP1R17 0.655
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TRPC7 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation SRF 0.276
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation SLC6A4 0.383
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation VASP 0.735
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates img/direct-activation.png phosphorylation PRKG1 0.345
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png phosphorylation ENAH 0.303
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png phosphorylation VASP 0.735
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png phosphorylation EVL 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance