| Name | CTTN |
| ID | Q14247 |
| Role | substrate |
| Enzymatic Domains |
SH3 492-550 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | CTTN | Tyr486 | YPAEDSTyDEYENDL | phosphorylation up-regulates activity | 20861316 | SIGNOR-278504 |
| PTPN1 | CTTN | Tyr446 | GTEPEPVySMEAADY | dephosphorylation up-regulates activity | 18387954 | SIGNOR-248432 |
| SRC | CTTN | Tyr421 | RLPSSPVyEDAASFK | phosphorylation down-regulates activity | 15169891 | SIGNOR-246513 |
| MAPK1 | CTTN | Ser405 | KTQTPPVsPAPQPTE | phosphorylation up-regulates | 20444238 | SIGNOR-165200 |
| PAK1 | CTTN | Ser405 | KTQTPPVsPAPQPTE | phosphorylation up-regulates | 21079800 | SIGNOR-169690 |
| PRKCD | CTTN | Ser418 | KTQTPPVsPAPQPTE | phosphorylation up-regulates activity | 26490115 | SIGNOR-260890 |
| PRKCD | CTTN | Ser405 | KTQTPPVsPAPQPTE | phosphorylation up-regulates activity | 26490115 | SIGNOR-260889 |
| PTPN1 | CTTN | Tyr421 | RLPSSPVyEDAASFK | dephosphorylation up-regulates activity | 27824079 | SIGNOR-277027 |
| SRC | CTTN | Tyr486 | YPAEDSTyDEYENDL | phosphorylation down-regulates | 12601080 | SIGNOR-98720 |
| SRC | CTTN | Tyr446 | GTEPEPVySMEAADY | phosphorylation down-regulates | 12601080 | SIGNOR-98712 |
| PRKD1 | CTTN | Ser298 | EKLAKHEsQQDYSKG | phosphorylation down-regulates | 20363754 | SIGNOR-164756 |
| PTPRG | CTTN | Tyr470 | AYATEAVyESAEAPG | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254696 |
| PRKD1 | CTTN | Ser348 | EAVTSKTsNIRANFE | phosphorylation down-regulates | 19038333 | SIGNOR-182502 |
| MAPK3 | CTTN | Ser405 | KTQTPPVsPAPQPTE | phosphorylation up-regulates | 20444238 | SIGNOR-165208 |
| PTK2 | CTTN | Tyr421 | RLPSSPVyEDAASFK | phosphorylation down-regulates activity | 22952866 | SIGNOR-278284 |
| MAPK3 | CTTN | Ser405 | KTQTPPVsPAPQPTE | phosphorylation up-regulates | 21079800 | SIGNOR-169682 |
| PTK2B | CTTN | Tyr486 | YPAEDSTyDEYENDL | phosphorylation up-regulates activity | 29133485 | SIGNOR-278345 |
| PTPN6 | CTTN | Tyr421 | RLPSSPVyEDAASFK | dephosphorylation down-regulates activity | 34088320 | SIGNOR-277003 |
| PAK1 | CTTN | Ser418 | TEERLPSsPVYEDAA | phosphorylation up-regulates | 21079800 | SIGNOR-169694 |
| FGFR1 | CTTN | Tyr446 | GTEPEPVySMEAADY | phosphorylation down-regulates | 12601080 | SIGNOR-98618 |
| MAPK3 | CTTN | Ser418 | TEERLPSsPVYEDAA | phosphorylation up-regulates | 21079800 | SIGNOR-169686 |
| PAK1 | CTTN | Ser418 | TEERLPSsPVYEDAA | phosphorylation up-regulates | 20444238 | SIGNOR-165220 |
| Gbeta | CTTN | – | phosphorylation up-regulates | 20444238 | SIGNOR-270051 | |
| MAPK1 | CTTN | Ser405 | KTQTPPVsPAPQPTE | phosphorylation up-regulates | 21079800 | SIGNOR-169674 |
| MAPK3 | CTTN | Ser418 | TEERLPSsPVYEDAA | phosphorylation up-regulates | 20444238 | SIGNOR-165212 |
| MAPK1 | CTTN | Ser418 | TEERLPSsPVYEDAA | phosphorylation up-regulates | 21079800 | SIGNOR-169678 |
| SRC | CTTN | Tyr470 | AYATEAVyESAEAPG | phosphorylation down-regulates | 12601080 | SIGNOR-98716 |
| PTK2B | CTTN | Tyr470 | AYATEAVyESAEAPG | phosphorylation up-regulates activity | 29133485 | SIGNOR-278344 |
| PAK1 | CTTN | Ser405 | KTQTPPVsPAPQPTE | phosphorylation up-regulates | 20444238 | SIGNOR-165216 |
| ERK1/2 | CTTN | – | phosphorylation up-regulates | 20444238 | SIGNOR-270164 | |
| MAPK1 | CTTN | Ser418 | TEERLPSsPVYEDAA | phosphorylation up-regulates | 20444238 | SIGNOR-165204 |
| PTK2 | CTTN | Tyr470 | AYATEAVyESAEAPG | phosphorylation down-regulates activity | 22952866 | SIGNOR-278283 |
| PTK2 | CTTN | Tyr486 | YPAEDSTyDEYENDL | phosphorylation down-regulates activity | 22952866 | SIGNOR-278285 |
| PTK2B | CTTN | Tyr421 | RLPSSPVyEDAASFK | phosphorylation up-regulates activity | 29133485 | SIGNOR-278343 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | phosphorylation up-regulates → | CTTN PTyr486 | phosphorylation up-regulates → | CTTN | 20861316 | SIGNOR-278504 |
| PTPN1 | dephosphorylation down-regulates ⊣ | CTTN PTyr446 | dephosphorylation down-regulates ⊣ | CTTN | 18387954 | SIGNOR-248432 |
| SRC | phosphorylation up-regulates → | CTTN PTyr421 | phosphorylation down-regulates ⊣ | CTTN | 15169891 | SIGNOR-246513 |
| MAPK1 | phosphorylation up-regulates → | CTTN PSer405 | phosphorylation up-regulates → | CTTN | 20444238 | SIGNOR-165200 |
| PAK1 | phosphorylation up-regulates → | CTTN PSer405 | phosphorylation up-regulates → | CTTN | 21079800 | SIGNOR-169690 |
| PRKCD | phosphorylation up-regulates → | CTTN PSer418 | phosphorylation up-regulates → | CTTN | 26490115 | SIGNOR-260890 |
| PRKCD | phosphorylation up-regulates → | CTTN PSer405 | phosphorylation up-regulates → | CTTN | 26490115 | SIGNOR-260889 |
| PTPN1 | dephosphorylation down-regulates ⊣ | CTTN PTyr421 | dephosphorylation down-regulates ⊣ | CTTN | 27824079 | SIGNOR-277027 |
| SRC | phosphorylation up-regulates → | CTTN PTyr486 | phosphorylation down-regulates ⊣ | CTTN | 12601080 | SIGNOR-98720 |
| SRC | phosphorylation up-regulates → | CTTN PTyr446 | phosphorylation down-regulates ⊣ | CTTN | 12601080 | SIGNOR-98712 |
| PRKD1 | phosphorylation up-regulates → | CTTN PSer298 | phosphorylation down-regulates ⊣ | CTTN | 20363754 | SIGNOR-164756 |
| PTPRG | dephosphorylation down-regulates ⊣ | CTTN PTyr470 | dephosphorylation up-regulates → | CTTN | 25624455 | SIGNOR-254696 |
| PRKD1 | phosphorylation up-regulates → | CTTN PSer348 | phosphorylation down-regulates ⊣ | CTTN | 19038333 | SIGNOR-182502 |
| MAPK3 | phosphorylation up-regulates → | CTTN PSer405 | phosphorylation up-regulates → | CTTN | 20444238 | SIGNOR-165208 |
| PTK2 | phosphorylation up-regulates → | CTTN PTyr421 | phosphorylation down-regulates ⊣ | CTTN | 22952866 | SIGNOR-278284 |
| MAPK3 | phosphorylation up-regulates → | CTTN PSer405 | phosphorylation up-regulates → | CTTN | 21079800 | SIGNOR-169682 |
| PTK2B | phosphorylation up-regulates → | CTTN PTyr486 | phosphorylation up-regulates → | CTTN | 29133485 | SIGNOR-278345 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CTTN PTyr421 | dephosphorylation up-regulates → | CTTN | 34088320 | SIGNOR-277003 |
| PAK1 | phosphorylation up-regulates → | CTTN PSer418 | phosphorylation up-regulates → | CTTN | 21079800 | SIGNOR-169694 |
| FGFR1 | phosphorylation up-regulates → | CTTN PTyr446 | phosphorylation down-regulates ⊣ | CTTN | 12601080 | SIGNOR-98618 |
| MAPK3 | phosphorylation up-regulates → | CTTN PSer418 | phosphorylation up-regulates → | CTTN | 21079800 | SIGNOR-169686 |
| PAK1 | phosphorylation up-regulates → | CTTN PSer418 | phosphorylation up-regulates → | CTTN | 20444238 | SIGNOR-165220 |
| MAPK1 | phosphorylation up-regulates → | CTTN PSer405 | phosphorylation up-regulates → | CTTN | 21079800 | SIGNOR-169674 |
| MAPK3 | phosphorylation up-regulates → | CTTN PSer418 | phosphorylation up-regulates → | CTTN | 20444238 | SIGNOR-165212 |
| MAPK1 | phosphorylation up-regulates → | CTTN PSer418 | phosphorylation up-regulates → | CTTN | 21079800 | SIGNOR-169678 |
| SRC | phosphorylation up-regulates → | CTTN PTyr470 | phosphorylation down-regulates ⊣ | CTTN | 12601080 | SIGNOR-98716 |
| PTK2B | phosphorylation up-regulates → | CTTN PTyr470 | phosphorylation up-regulates → | CTTN | 29133485 | SIGNOR-278344 |
| PAK1 | phosphorylation up-regulates → | CTTN PSer405 | phosphorylation up-regulates → | CTTN | 20444238 | SIGNOR-165216 |
| MAPK1 | phosphorylation up-regulates → | CTTN PSer418 | phosphorylation up-regulates → | CTTN | 20444238 | SIGNOR-165204 |
| PTK2 | phosphorylation up-regulates → | CTTN PTyr470 | phosphorylation down-regulates ⊣ | CTTN | 22952866 | SIGNOR-278283 |
| PTK2 | phosphorylation up-regulates → | CTTN PTyr486 | phosphorylation down-regulates ⊣ | CTTN | 22952866 | SIGNOR-278285 |
| PTK2B | phosphorylation up-regulates → | CTTN PTyr421 | phosphorylation up-regulates → | CTTN | 29133485 | SIGNOR-278343 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ABL1 | phosphorylation → up-regulates activity | CTTN | SIGNOR-278504 |
| PTPN1 | dephosphorylation → up-regulates activity | CTTN | SIGNOR-248432 |
| SRC | phosphorylation → down-regulates activity | CTTN | SIGNOR-246513 |
| MAPK1 | phosphorylation → up-regulates | CTTN | SIGNOR-165200 |
| PAK1 | phosphorylation → up-regulates | CTTN | SIGNOR-169690 |
| PRKCD | phosphorylation → up-regulates activity | CTTN | SIGNOR-260890 |
| PRKCD | phosphorylation → up-regulates activity | CTTN | SIGNOR-260889 |
| PTPN1 | dephosphorylation → up-regulates activity | CTTN | SIGNOR-277027 |
| SRC | phosphorylation down-regulates | CTTN | SIGNOR-98720 |
| SRC | phosphorylation down-regulates | CTTN | SIGNOR-98712 |
| PRKD1 | phosphorylation down-regulates | CTTN | SIGNOR-164756 |
| PTPRG | dephosphorylation → down-regulates activity | CTTN | SIGNOR-254696 |
| PRKD1 | phosphorylation down-regulates | CTTN | SIGNOR-182502 |
| MAPK3 | phosphorylation → up-regulates | CTTN | SIGNOR-165208 |
| PTK2 | phosphorylation → down-regulates activity | CTTN | SIGNOR-278284 |
| MAPK3 | phosphorylation → up-regulates | CTTN | SIGNOR-169682 |
| PTK2B | phosphorylation → up-regulates activity | CTTN | SIGNOR-278345 |
| PTPN6 | dephosphorylation → down-regulates activity | CTTN | SIGNOR-277003 |
| PAK1 | phosphorylation → up-regulates | CTTN | SIGNOR-169694 |
| FGFR1 | phosphorylation down-regulates | CTTN | SIGNOR-98618 |
| MAPK3 | phosphorylation → up-regulates | CTTN | SIGNOR-169686 |
| PAK1 | phosphorylation → up-regulates | CTTN | SIGNOR-165220 |
| Gbeta | phosphorylation → up-regulates | CTTN | SIGNOR-270051 |
| MAPK1 | phosphorylation → up-regulates | CTTN | SIGNOR-169674 |
| MAPK3 | phosphorylation → up-regulates | CTTN | SIGNOR-165212 |
| MAPK1 | phosphorylation → up-regulates | CTTN | SIGNOR-169678 |
| SRC | phosphorylation down-regulates | CTTN | SIGNOR-98716 |
| PTK2B | phosphorylation → up-regulates activity | CTTN | SIGNOR-278344 |
| PAK1 | phosphorylation → up-regulates | CTTN | SIGNOR-165216 |
| ERK1/2 | phosphorylation → up-regulates | CTTN | SIGNOR-270164 |
| MAPK1 | phosphorylation → up-regulates | CTTN | SIGNOR-165204 |
| PTK2 | phosphorylation → down-regulates activity | CTTN | SIGNOR-278283 |
| PTK2 | phosphorylation → down-regulates activity | CTTN | SIGNOR-278285 |
| PTK2B | phosphorylation → up-regulates activity | CTTN | SIGNOR-278343 |