Summary

Name CTTN
Full Name Src substrate cortactin
Synonyms Amplaxin, Oncogene EMS1 | EMS1
Primary ID Q14247
Links - -
Type protein
Relations 23
Pathways T cell activation
Function Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation CTTN 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTTN 0.28
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTTN 0.28
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CTTN 0.37
Publications: 4 Organism: Homo Sapiens
Pathways:T cell activation
+ down-regulates activity img/direct_inhibition.png phosphorylation CTTN 0.34
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CTTN 0.14
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png phosphorylation CTTN 0.34
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTTN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CTTN 0.22
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png dephosphorylation CTTN 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding ARP2/3 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation