| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FGFR1 | CTTN | Tyr446 | GTEPEPVySMEAADY | phosphorylation down-regulates | 12601080 | SIGNOR-98618 |
| SRC | CTTN | Tyr446 | GTEPEPVySMEAADY | phosphorylation down-regulates | 12601080 | SIGNOR-98712 |
| PTPN1 | CTTN | Tyr446 | GTEPEPVySMEAADY | dephosphorylation up-regulates activity | 18387954 | SIGNOR-248432 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FGFR1 | phosphorylation up-regulates → | CTTN PTyr446 | phosphorylation down-regulates ⊣ | CTTN | 12601080 | SIGNOR-98618 |
| SRC | phosphorylation up-regulates → | CTTN PTyr446 | phosphorylation down-regulates ⊣ | CTTN | 12601080 | SIGNOR-98712 |
| PTPN1 | dephosphorylation down-regulates ⊣ | CTTN PTyr446 | dephosphorylation down-regulates ⊣ | CTTN | 18387954 | SIGNOR-248432 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FGFR1 | phosphorylation down-regulates | CTTN | SIGNOR-98618 |
| SRC | phosphorylation down-regulates | CTTN | SIGNOR-98712 |
| PTPN1 | dephosphorylation → up-regulates activity | CTTN | SIGNOR-248432 |
