Entity Details

Name SRC_Tyr421
ID Q14247
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPN6CTTNTyr421RLPSSPVyEDAASFKdephosphorylation
down-regulates activity		34088320SIGNOR-277003
PTK2BCTTNTyr421RLPSSPVyEDAASFKphosphorylation
up-regulates activity		29133485SIGNOR-278343
PTPN1CTTNTyr421RLPSSPVyEDAASFKdephosphorylation
up-regulates activity		27824079SIGNOR-277027
PTK2CTTNTyr421RLPSSPVyEDAASFKphosphorylation
down-regulates activity		22952866SIGNOR-278284
SRCCTTNTyr421RLPSSPVyEDAASFKphosphorylation
down-regulates activity		15169891SIGNOR-246513
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPN6dephosphorylation
down-regulates
⊣
CTTN
PTyr421		dephosphorylation
up-regulates
→		CTTN34088320SIGNOR-277003
PTK2Bphosphorylation
up-regulates
→
CTTN
PTyr421		phosphorylation
up-regulates
→		CTTN29133485SIGNOR-278343
PTPN1dephosphorylation
down-regulates
⊣
CTTN
PTyr421		dephosphorylation
down-regulates
⊣		CTTN27824079SIGNOR-277027
PTK2phosphorylation
up-regulates
→
CTTN
PTyr421		phosphorylation
down-regulates
⊣		CTTN22952866SIGNOR-278284
SRCphosphorylation
up-regulates
→
CTTN
PTyr421		phosphorylation
down-regulates
⊣		CTTN15169891SIGNOR-246513
Regulator Mechanism/Effect Target SIGNOR-ID
PTPN6dephosphorylation
→
down-regulates activity 		CTTNSIGNOR-277003
PTK2Bphosphorylation
→
up-regulates activity 		CTTNSIGNOR-278343
PTPN1dephosphorylation
→
up-regulates activity 		CTTNSIGNOR-277027
PTK2phosphorylation
→
down-regulates activity 		CTTNSIGNOR-278284
SRCphosphorylation
→
down-regulates activity 		CTTNSIGNOR-246513