| Name | PTK2B |
| ID | Q14289 |
| Role | kinase |
| Enzymatic Domains |
FERM 39-359 PROSITE-ProRule
Protein kinase 425-683 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2B | NPHP1 | Tyr349 | GNQFRANyFLQPELM | phosphorylation up-regulates activity | 21357692 | SIGNOR-278271 |
| PTK2B | NPHP1 | Tyr46 | PNKRQHIyQRCIQLK | phosphorylation up-regulates activity | 21357692 | SIGNOR-278272 |
| PTK2B | NPHP1 | Tyr721 | FDLSEQTyDFLGEMR | phosphorylation up-regulates activity | 21357692 | SIGNOR-278273 |
| PTK2B | ASAP2 | – | phosphorylation up-regulates activity | 10022920 | SIGNOR-269704 | |
| PTK2B | TGFB1I1 | Tyr60 | SGDKDHLySTVCKPR | phosphorylation up-regulates activity | 10838081 | SIGNOR-262876 |
| PTK2B | GSN | – | phosphorylation down-regulates activity | 12578912 | SIGNOR-278325 | |
| PTK2B | NOS3 | Tyr657 | FGLGSRAyPHFCAFA | phosphorylation down-regulates | 18483407 | SIGNOR-178648 |
| PTK2B | NOS3 | Tyr657 | FGLGSRAyPHFCAFA | phosphorylation down-regulates | 19934023 | SIGNOR-161824 |
| PTK2B | SNCA | Tyr125 | VDPDNEAyEMPSEEG | phosphorylation unknown | 12096713 | SIGNOR-249151 |
| PTK2B | STAT3 | – | phosphorylation up-regulates activity | 26084289 | SIGNOR-279429 | |
| PTK2B | PXN | – | phosphorylation down-regulates quantity by destabilization | 15263022 | SIGNOR-279272 | |
| PTK2B | BCAR1 | – | phosphorylation up-regulates activity | 15263022 | SIGNOR-280100 | |
| PTK2B | ID3 | – | phosphorylation up-regulates quantity | 25090023 | SIGNOR-278496 | |
| PTK2B | PTK2 | Tyr407 | IIDEEDTyTMPSTRD | phosphorylation up-regulates | 16760434 | SIGNOR-147070 |
| PTK2B | CTTN | Tyr421 | RLPSSPVyEDAASFK | phosphorylation up-regulates activity | 29133485 | SIGNOR-278343 |
| PTK2B | CTTN | Tyr470 | AYATEAVyESAEAPG | phosphorylation up-regulates activity | 29133485 | SIGNOR-278344 |
| PTK2B | CTTN | Tyr486 | YPAEDSTyDEYENDL | phosphorylation up-regulates activity | 29133485 | SIGNOR-278345 |
| PTK2B | PTK2B | Tyr402 | CSIESDIyAEIPDET | phosphorylation up-regulates | 15105428 | SIGNOR-124339 |
| PTK2B | LSR | – | phosphorylation up-regulates activity | 31574128 | SIGNOR-280101 | |
| PTK2B | TBK1 | Tyr591 | KFDKQKLyYHATKAM | phosphorylation up-regulates activity | 37989995 | SIGNOR-277910 |
| PTK2B | ASAP1 | Tyr323 | QLQGNKEyGSEKKGY | phosphorylation down-regulates activity | 12771146 | SIGNOR-263186 |
| PTK2B | ASAP1 | Tyr767 | RDKQRLSyGAFTNQI | phosphorylation down-regulates activity | 12771146 | SIGNOR-263187 |
| PTK2B | STAP1 | – | phosphorylation up-regulates activity | 10518561 | SIGNOR-261818 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2B | phosphorylation up-regulates → | NPHP1 PTyr349 | phosphorylation up-regulates → | NPHP1 | 21357692 | SIGNOR-278271 |
| PTK2B | phosphorylation up-regulates → | NPHP1 PTyr46 | phosphorylation up-regulates → | NPHP1 | 21357692 | SIGNOR-278272 |
| PTK2B | phosphorylation up-regulates → | NPHP1 PTyr721 | phosphorylation up-regulates → | NPHP1 | 21357692 | SIGNOR-278273 |
| PTK2B | phosphorylation up-regulates → | TGFB1I1 PTyr60 | phosphorylation up-regulates → | TGFB1I1 | 10838081 | SIGNOR-262876 |
| PTK2B | phosphorylation up-regulates → | NOS3 PTyr657 | phosphorylation down-regulates ⊣ | NOS3 | 18483407 | SIGNOR-178648 |
| PTK2B | phosphorylation up-regulates → | NOS3 PTyr657 | phosphorylation down-regulates ⊣ | NOS3 | 19934023 | SIGNOR-161824 |
| PTK2B | phosphorylation up-regulates → | SNCA PTyr125 | phosphorylation down-regulates ⊣ | SNCA | 12096713 | SIGNOR-249151 |
| PTK2B | phosphorylation up-regulates → | PTK2 PTyr407 | phosphorylation up-regulates → | PTK2 | 16760434 | SIGNOR-147070 |
| PTK2B | phosphorylation up-regulates → | CTTN PTyr421 | phosphorylation up-regulates → | CTTN | 29133485 | SIGNOR-278343 |
| PTK2B | phosphorylation up-regulates → | CTTN PTyr470 | phosphorylation up-regulates → | CTTN | 29133485 | SIGNOR-278344 |
| PTK2B | phosphorylation up-regulates → | CTTN PTyr486 | phosphorylation up-regulates → | CTTN | 29133485 | SIGNOR-278345 |
| PTK2B | phosphorylation up-regulates → | PTK2B PTyr402 | phosphorylation up-regulates → | PTK2B | 15105428 | SIGNOR-124339 |
| PTK2B | phosphorylation up-regulates → | TBK1 PTyr591 | phosphorylation up-regulates → | TBK1 | 37989995 | SIGNOR-277910 |
| PTK2B | phosphorylation up-regulates → | ASAP1 PTyr323 | phosphorylation down-regulates ⊣ | ASAP1 | 12771146 | SIGNOR-263186 |
| PTK2B | phosphorylation up-regulates → | ASAP1 PTyr767 | phosphorylation down-regulates ⊣ | ASAP1 | 12771146 | SIGNOR-263187 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTK2B | phosphorylation → up-regulates activity | NPHP1 | SIGNOR-278271 |
| PTK2B | phosphorylation → up-regulates activity | NPHP1 | SIGNOR-278272 |
| PTK2B | phosphorylation → up-regulates activity | NPHP1 | SIGNOR-278273 |
| PTK2B | phosphorylation → up-regulates activity | ASAP2 | SIGNOR-269704 |
| PTK2B | phosphorylation → up-regulates activity | TGFB1I1 | SIGNOR-262876 |
| PTK2B | phosphorylation → down-regulates activity | GSN | SIGNOR-278325 |
| PTK2B | phosphorylation down-regulates | NOS3 | SIGNOR-178648 |
| PTK2B | phosphorylation down-regulates | NOS3 | SIGNOR-161824 |
| PTK2B | phosphorylation → unknown | SNCA | SIGNOR-249151 |
| PTK2B | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279429 |
| PTK2B | phosphorylation down-regulates quantity by destabilization | PXN | SIGNOR-279272 |
| PTK2B | phosphorylation → up-regulates activity | BCAR1 | SIGNOR-280100 |
| PTK2B | phosphorylation → up-regulates quantity | ID3 | SIGNOR-278496 |
| PTK2B | phosphorylation → up-regulates | PTK2 | SIGNOR-147070 |
| PTK2B | phosphorylation → up-regulates activity | CTTN | SIGNOR-278343 |
| PTK2B | phosphorylation → up-regulates activity | CTTN | SIGNOR-278344 |
| PTK2B | phosphorylation → up-regulates activity | CTTN | SIGNOR-278345 |
| PTK2B | phosphorylation → up-regulates | PTK2B | SIGNOR-124339 |
| PTK2B | phosphorylation → up-regulates activity | LSR | SIGNOR-280101 |
| PTK2B | phosphorylation → up-regulates activity | TBK1 | SIGNOR-277910 |
| PTK2B | phosphorylation → down-regulates activity | ASAP1 | SIGNOR-263186 |
| PTK2B | phosphorylation → down-regulates activity | ASAP1 | SIGNOR-263187 |
| PTK2B | phosphorylation → up-regulates activity | STAP1 | SIGNOR-261818 |