Summary
Name | PTK2B View Modifications |
Full Name | Protein-tyrosine kinase 2-beta |
Synonyms | Calcium-dependent tyrosine kinase, CADTK, Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta, CAK-beta, CAKB, Focal adhesion kinase 2, FADK 2, Proline-rich tyrosine kinase 2, Related adhesion focal tyrosine kinase, RAFTK | FAK2, PYK2, RAFTK |
Primary ID | Q14289 |
Links | - - |
Type | protein |
Relations | 16 |
Inhibitors | N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]methanesulfonamide |
Function | Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Modifications Tables
Relations
Regulator | Mechanism | target | score ℹ | |
---|---|---|---|---|
+ | PTK2B | phosphorylation | SNCA | 0.32 |
Publications: | 1 | Organism: | Chlorocebus Aethiops | |
+ | PTK2B | down-regulates activity phosphorylation | ASAP1 | 0.471 |
Publications: | 2 | Organism: | Homo Sapiens | |
+ | PTK2B | up-regulates phosphorylation | PTK2B | 0.2 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | SRC | up-regulates phosphorylation | PTK2B | 0.603 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | PTPN6 | down-regulates dephosphorylation | PTK2B | 0.366 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | PTPN12 | down-regulates activity dephosphorylation | PTK2B | 0.567 |
Publications: | 3 | Organism: | Rattus Norvegicus, Homo Sapiens | |
+ | PTK2B | up-regulates phosphorylation | PTK2 | 0.497 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | PTK2B | up-regulates activity phosphorylation | TGFB1I1 | 0.74 |
Publications: | 1 | Organism: | Chlorocebus Aethiops | |
+ | PTK2B | down-regulates phosphorylation | NOS3 | 0.317 |
Publications: | 2 | Organism: | Homo Sapiens | |
+ | N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]methanesulfonamide | down-regulates chemical inhibition | PTK2B | 0.8 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | PTK2B | up-regulates activity phosphorylation | STAP1 | 0.358 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | PTK2B | up-regulates activity phosphorylation | ASAP2 | 0.546 |
Publications: | 1 | Organism: | Homo Sapiens | |