| Name | PTK2B |
| ID | Q14289 |
| Role | substrate |
| Enzymatic Domains |
FERM 39-359 PROSITE-ProRule
Protein kinase 425-683 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN12 | PTK2B | Tyr580 | YIEDEDYyKASVTRL | dephosphorylation down-regulates activity | 11337490 | SIGNOR-248664 |
| PTPN6 | PTK2B | Tyr402 | CSIESDIyAEIPDET | dephosphorylation down-regulates | 10521452 | SIGNOR-71414 |
| PTPN12 | PTK2B | Tyr579 | RYIEDEDyYKASVTR | dephosphorylation down-regulates activity | 11337490 | SIGNOR-107502 |
| PTPN12 | PTK2B | Tyr402 | CSIESDIyAEIPDET | dephosphorylation down-regulates activity | 11337490 | SIGNOR-248662 |
| SRC | PTK2B | Tyr402 | CSIESDIyAEIPDET | phosphorylation up-regulates | 15695828 | SIGNOR-133870 |
| MET | PTK2B | – | phosphorylation up-regulates activity | 22188814 | SIGNOR-280040 | |
| PTK2B | PTK2B | Tyr402 | CSIESDIyAEIPDET | phosphorylation up-regulates | 15105428 | SIGNOR-124339 |
| PTPN11 | PTK2B | Tyr906 | CQLPPEGyVVVVKNV | dephosphorylation down-regulates activity | 10880513 | SIGNOR-277084 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN12 | dephosphorylation down-regulates ⊣ | PTK2B PTyr580 | dephosphorylation up-regulates → | PTK2B | 11337490 | SIGNOR-248664 |
| PTPN6 | dephosphorylation down-regulates ⊣ | PTK2B PTyr402 | dephosphorylation up-regulates → | PTK2B | 10521452 | SIGNOR-71414 |
| PTPN12 | dephosphorylation down-regulates ⊣ | PTK2B PTyr579 | dephosphorylation up-regulates → | PTK2B | 11337490 | SIGNOR-107502 |
| PTPN12 | dephosphorylation down-regulates ⊣ | PTK2B PTyr402 | dephosphorylation up-regulates → | PTK2B | 11337490 | SIGNOR-248662 |
| SRC | phosphorylation up-regulates → | PTK2B PTyr402 | phosphorylation up-regulates → | PTK2B | 15695828 | SIGNOR-133870 |
| PTK2B | phosphorylation up-regulates → | PTK2B PTyr402 | phosphorylation up-regulates → | PTK2B | 15105428 | SIGNOR-124339 |
| PTPN11 | dephosphorylation down-regulates ⊣ | PTK2B PTyr906 | dephosphorylation up-regulates → | PTK2B | 10880513 | SIGNOR-277084 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN12 | dephosphorylation → down-regulates activity | PTK2B | SIGNOR-248664 |
| PTPN6 | dephosphorylation down-regulates | PTK2B | SIGNOR-71414 |
| PTPN12 | dephosphorylation → down-regulates activity | PTK2B | SIGNOR-107502 |
| PTPN12 | dephosphorylation → down-regulates activity | PTK2B | SIGNOR-248662 |
| SRC | phosphorylation → up-regulates | PTK2B | SIGNOR-133870 |
| MET | phosphorylation → up-regulates activity | PTK2B | SIGNOR-280040 |
| PTK2B | phosphorylation → up-regulates | PTK2B | SIGNOR-124339 |
| PTPN11 | dephosphorylation → down-regulates activity | PTK2B | SIGNOR-277084 |