| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | PTK2B | Tyr402 | CSIESDIyAEIPDET | dephosphorylation down-regulates | 10521452 | SIGNOR-71414 |
| PTPN12 | PTK2B | Tyr402 | CSIESDIyAEIPDET | dephosphorylation down-regulates activity | 11337490 | SIGNOR-248662 |
| SRC | PTK2B | Tyr402 | CSIESDIyAEIPDET | phosphorylation up-regulates | 15695828 | SIGNOR-133870 |
| PTK2B | PTK2B | Tyr402 | CSIESDIyAEIPDET | phosphorylation up-regulates | 15105428 | SIGNOR-124339 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN6 | dephosphorylation down-regulates ⊣ | PTK2B PTyr402 | dephosphorylation up-regulates → | PTK2B | 10521452 | SIGNOR-71414 |
| PTPN12 | dephosphorylation down-regulates ⊣ | PTK2B PTyr402 | dephosphorylation up-regulates → | PTK2B | 11337490 | SIGNOR-248662 |
| SRC | phosphorylation up-regulates → | PTK2B PTyr402 | phosphorylation up-regulates → | PTK2B | 15695828 | SIGNOR-133870 |
| PTK2B | phosphorylation up-regulates → | PTK2B PTyr402 | phosphorylation up-regulates → | PTK2B | 15105428 | SIGNOR-124339 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN6 | dephosphorylation down-regulates | PTK2B | SIGNOR-71414 |
| PTPN12 | dephosphorylation → down-regulates activity | PTK2B | SIGNOR-248662 |
| SRC | phosphorylation → up-regulates | PTK2B | SIGNOR-133870 |
| PTK2B | phosphorylation → up-regulates | PTK2B | SIGNOR-124339 |
