| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN12 | PTK2B | Tyr580 | YIEDEDYyKASVTRL | dephosphorylation down-regulates activity | 11337490 | SIGNOR-248664 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN12 | dephosphorylation down-regulates ⊣ | PTK2B PTyr580 | dephosphorylation up-regulates → | PTK2B | 11337490 | SIGNOR-248664 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN12 | dephosphorylation → down-regulates activity | PTK2B | SIGNOR-248664 |
