| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | PTK2B | Tyr906 | CQLPPEGyVVVVKNV | dephosphorylation down-regulates activity | 10880513 | SIGNOR-277084 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | dephosphorylation down-regulates ⊣ | PTK2B PTyr906 | dephosphorylation up-regulates → | PTK2B | 10880513 | SIGNOR-277084 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN11 | dephosphorylation → down-regulates activity | PTK2B | SIGNOR-277084 |
