Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
GSK3B	GRB14	Ser358	MHPYQGRsGCSSQSI	phosphorylation down-regulates activity	28130417	SIGNOR-264868
GSK3B	GRB14	Ser366	GCSSQSIsPMRSISE	phosphorylation down-regulates activity	28130417	SIGNOR-264869
GSK3B	GRB14	Ser362	QGRSGCSsQSISPMR	phosphorylation down-regulates activity	28130417	SIGNOR-264867
GSK3A	GRB14	Ser362	QGRSGCSsQSISPMR	phosphorylation down-regulates activity	28130417	SIGNOR-264870
TEK	GRB14	–		phosphorylation up-regulates activity	20973951	SIGNOR-279300
GSK3A	GRB14	Ser366	GCSSQSIsPMRSISE	phosphorylation down-regulates activity	28130417	SIGNOR-264872
GSK3A	GRB14	Ser358	MHPYQGRsGCSSQSI	phosphorylation down-regulates activity	28130417	SIGNOR-264871

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
GSK3B	phosphorylation up-regulates →	GRB14 PSer358	phosphorylation down-regulates ⊣	GRB14	28130417	SIGNOR-264868
GSK3B	phosphorylation up-regulates →	GRB14 PSer366	phosphorylation down-regulates ⊣	GRB14	28130417	SIGNOR-264869
GSK3B	phosphorylation up-regulates →	GRB14 PSer362	phosphorylation down-regulates ⊣	GRB14	28130417	SIGNOR-264867
GSK3A	phosphorylation up-regulates →	GRB14 PSer362	phosphorylation down-regulates ⊣	GRB14	28130417	SIGNOR-264870
GSK3A	phosphorylation up-regulates →	GRB14 PSer366	phosphorylation down-regulates ⊣	GRB14	28130417	SIGNOR-264872
GSK3A	phosphorylation up-regulates →	GRB14 PSer358	phosphorylation down-regulates ⊣	GRB14	28130417	SIGNOR-264871

Regulator	Mechanism/Effect	Target	SIGNOR-ID
GSK3B	phosphorylation → down-regulates activity	GRB14	SIGNOR-264868
GSK3B	phosphorylation → down-regulates activity	GRB14	SIGNOR-264869
GSK3B	phosphorylation → down-regulates activity	GRB14	SIGNOR-264867
GSK3A	phosphorylation → down-regulates activity	GRB14	SIGNOR-264870
TEK	phosphorylation → up-regulates activity	GRB14	SIGNOR-279300
GSK3A	phosphorylation → down-regulates activity	GRB14	SIGNOR-264872
GSK3A	phosphorylation → down-regulates activity	GRB14	SIGNOR-264871