Summary

Name GRB14
Full Name Growth factor receptor-bound protein 14
Synonyms GRB14 adapter protein |
Primary ID Q14449
Links - -
Type protein
Relations 7
Function Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation GRB14 0.268
Publications: 3 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation GRB14 0.328
Publications: 3 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding INSR 0.746
Publications: 1