| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3A | GRB14 | Ser358 | MHPYQGRsGCSSQSI | phosphorylation down-regulates activity | 28130417 | SIGNOR-264871 |
| GSK3B | GRB14 | Ser358 | MHPYQGRsGCSSQSI | phosphorylation down-regulates activity | 28130417 | SIGNOR-264868 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3A | phosphorylation up-regulates → | GRB14 PSer358 | phosphorylation down-regulates ⊣ | GRB14 | 28130417 | SIGNOR-264871 |
| GSK3B | phosphorylation up-regulates → | GRB14 PSer358 | phosphorylation down-regulates ⊣ | GRB14 | 28130417 | SIGNOR-264868 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3A | phosphorylation → down-regulates activity | GRB14 | SIGNOR-264871 |
| GSK3B | phosphorylation → down-regulates activity | GRB14 | SIGNOR-264868 |