| Name | GRB7 |
| ID | Q14451 |
| Role | substrate |
| Enzymatic Domains |
Ras-associating 100-186 PROSITE-ProRule
PH 229-338 PROSITE-ProRule
SH2 431-527 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | GRB7 | Ser194 | KYELFKSsPHSLFPE | phosphorylation down-regulates quantity by destabilization | 27658202 | SIGNOR-277280 |
| PTPN11 | GRB7 | – | dephosphorylation up-regulates activity | 20142421 | SIGNOR-277169 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | GRB7 PSer194 | phosphorylation down-regulates ⊣ | GRB7 | 27658202 | SIGNOR-277280 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation down-regulates quantity by destabilization | GRB7 | SIGNOR-277280 |
| PTPN11 | dephosphorylation → up-regulates activity | GRB7 | SIGNOR-277169 |