| Name | ESPL1 |
| ID | Q14674 |
| Role | substrate |
| Enzymatic Domains |
Peptidase C50 1945-2040 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | ESPL1 | Ser1399 | KVNFSDDsDLEDPVS | phosphorylation down-regulates activity | 17974570 | SIGNOR-276082 |
| MAPK1 | ESPL1 | Ser1126 | IAPSTNSsPVLKTKP | phosphorylation down-regulates | 11747808 | SIGNOR-113130 |
| PLK1 | ESPL1 | Thr1363 | AGPHVPFtVFEEVCP | phosphorylation down-regulates activity | 17974570 | SIGNOR-276083 |
| CDK1 | ESPL1 | Ser1126 | IAPSTNSsPVLKTKP | phosphorylation down-regulates | 11747808 | SIGNOR-113126 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | ESPL1 PSer1399 | phosphorylation down-regulates ⊣ | ESPL1 | 17974570 | SIGNOR-276082 |
| MAPK1 | phosphorylation up-regulates → | ESPL1 PSer1126 | phosphorylation down-regulates ⊣ | ESPL1 | 11747808 | SIGNOR-113130 |
| PLK1 | phosphorylation up-regulates → | ESPL1 PThr1363 | phosphorylation down-regulates ⊣ | ESPL1 | 17974570 | SIGNOR-276083 |
| CDK1 | phosphorylation up-regulates → | ESPL1 PSer1126 | phosphorylation down-regulates ⊣ | ESPL1 | 11747808 | SIGNOR-113126 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → down-regulates activity | ESPL1 | SIGNOR-276082 |
| MAPK1 | phosphorylation down-regulates | ESPL1 | SIGNOR-113130 |
| PLK1 | phosphorylation → down-regulates activity | ESPL1 | SIGNOR-276083 |
| CDK1 | phosphorylation down-regulates | ESPL1 | SIGNOR-113126 |