4.0
Summary
| Name |  ESPL1View Modifications |
| Full Name | Separin |
| Synonyms | Caspase-like protein ESPL1, Extra spindle poles-like 1 protein, Separase | ESP1, KIAA0165 |
| Primary ID | Q14674 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK1 | down-regulates 
phosphorylation
|
ESPL1 | 0.56 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK1 | down-regulates
phosphorylation
|
ESPL1 | 0.273 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PLK1 | down-regulates activity
phosphorylation
|
ESPL1 | 0.784 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PTTG1 | down-regulates activity
binding
|
ESPL1 | 0.947 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ESPL1 | down-regulates quantity by destabilization
cleavage
|
RAD21 | 0.792 |
| Publications: | 1 | Organism: | Homo Sapiens | |