| Name | CASP8 |
| ID | Q14790 |
| Role | substrate |
| Enzymatic Domains |
DED 1 2-80 PROSITE-ProRule
DED 2 100-177 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | CASP8 | Ser387 | YLEMDLSsPQTRYIP | phosphorylation down-regulates | 20937773 | SIGNOR-168446 |
| LYN | CASP8 | Tyr448 | TILTEVNyEVSNKDD | phosphorylation down-regulates activity | 18086677 | SIGNOR-272980 |
| SRC | CASP8 | Tyr380 | TDSEEQPyLEMDLSS | phosphorylation down-regulates | 16619028 | SIGNOR-146127 |
| PTPN6 | CASP8 | Tyr448 | TILTEVNyEVSNKDD | dephosphorylation up-regulates activity | 18086677 | SIGNOR-248478 |
| Gbeta | CASP8 | – | phosphorylation down-regulates | 24342355 | SIGNOR-270118 | |
| LYN | CASP8 | Tyr380 | TDSEEQPyLEMDLSS | phosphorylation down-regulates activity | 18086677 | SIGNOR-272979 |
| RPS6KA3 | CASP8 | Thr263 | SIRDRNGtHLDAGAL | phosphorylation down-regulates quantity by destabilization | 21183680 | SIGNOR-272997 |
| PLK1 | CASP8 | Ser305 | IYQLMDHsNMDCFIC | phosphorylation down-regulates quantity by destabilization | 24484936 | SIGNOR-272989 |
| PLK3 | CASP8 | Thr273 | DAGALTTtFEELHFE | phosphorylation up-regulates activity | 27325299 | SIGNOR-272995 |
| ERK1/2 | CASP8 | Ser387 | YLEMDLSsPQTRYIP | phosphorylation down-regulates | 24342355 | SIGNOR-244509 |
| CyclinB/CDK1 | CASP8 | Ser387 | YLEMDLSsPQTRYIP | phosphorylation down-regulates | 20937773 | SIGNOR-216737 |
| MAPK1 | CASP8 | Ser387 | YLEMDLSsPQTRYIP | phosphorylation down-regulates | 24342355 | SIGNOR-203473 |
| PTPN6 | CASP8 | Tyr380 | TDSEEQPyLEMDLSS | dephosphorylation up-regulates activity | 18086677 | SIGNOR-248477 |
| MAPK3 | CASP8 | Ser387 | YLEMDLSsPQTRYIP | phosphorylation down-regulates | 24342355 | SIGNOR-203480 |
| MAPK14 | CASP8 | Ser347 | FTGLKCPsLAGKPKV | phosphorylation down-regulates | 14970175 | SIGNOR-122103 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | CASP8 PSer387 | phosphorylation down-regulates ⊣ | CASP8 | 20937773 | SIGNOR-168446 |
| LYN | phosphorylation up-regulates → | CASP8 PTyr448 | phosphorylation down-regulates ⊣ | CASP8 | 18086677 | SIGNOR-272980 |
| SRC | phosphorylation up-regulates → | CASP8 PTyr380 | phosphorylation down-regulates ⊣ | CASP8 | 16619028 | SIGNOR-146127 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CASP8 PTyr448 | dephosphorylation down-regulates ⊣ | CASP8 | 18086677 | SIGNOR-248478 |
| LYN | phosphorylation up-regulates → | CASP8 PTyr380 | phosphorylation down-regulates ⊣ | CASP8 | 18086677 | SIGNOR-272979 |
| RPS6KA3 | phosphorylation up-regulates → | CASP8 PThr263 | phosphorylation down-regulates ⊣ | CASP8 | 21183680 | SIGNOR-272997 |
| PLK1 | phosphorylation up-regulates → | CASP8 PSer305 | phosphorylation down-regulates ⊣ | CASP8 | 24484936 | SIGNOR-272989 |
| PLK3 | phosphorylation up-regulates → | CASP8 PThr273 | phosphorylation up-regulates → | CASP8 | 27325299 | SIGNOR-272995 |
| ERK1/2 | phosphorylation up-regulates → | CASP8 PSer387 | phosphorylation down-regulates ⊣ | CASP8 | 24342355 | SIGNOR-244509 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CASP8 PSer387 | phosphorylation down-regulates ⊣ | CASP8 | 20937773 | SIGNOR-216737 |
| MAPK1 | phosphorylation up-regulates → | CASP8 PSer387 | phosphorylation down-regulates ⊣ | CASP8 | 24342355 | SIGNOR-203473 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CASP8 PTyr380 | dephosphorylation down-regulates ⊣ | CASP8 | 18086677 | SIGNOR-248477 |
| MAPK3 | phosphorylation up-regulates → | CASP8 PSer387 | phosphorylation down-regulates ⊣ | CASP8 | 24342355 | SIGNOR-203480 |
| MAPK14 | phosphorylation up-regulates → | CASP8 PSer347 | phosphorylation down-regulates ⊣ | CASP8 | 14970175 | SIGNOR-122103 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation down-regulates | CASP8 | SIGNOR-168446 |
| LYN | phosphorylation → down-regulates activity | CASP8 | SIGNOR-272980 |
| SRC | phosphorylation down-regulates | CASP8 | SIGNOR-146127 |
| PTPN6 | dephosphorylation → up-regulates activity | CASP8 | SIGNOR-248478 |
| Gbeta | phosphorylation down-regulates | CASP8 | SIGNOR-270118 |
| LYN | phosphorylation → down-regulates activity | CASP8 | SIGNOR-272979 |
| RPS6KA3 | phosphorylation down-regulates quantity by destabilization | CASP8 | SIGNOR-272997 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | CASP8 | SIGNOR-272989 |
| PLK3 | phosphorylation → up-regulates activity | CASP8 | SIGNOR-272995 |
| ERK1/2 | phosphorylation down-regulates | CASP8 | SIGNOR-244509 |
| CyclinB/CDK1 | phosphorylation down-regulates | CASP8 | SIGNOR-216737 |
| MAPK1 | phosphorylation down-regulates | CASP8 | SIGNOR-203473 |
| PTPN6 | dephosphorylation → up-regulates activity | CASP8 | SIGNOR-248477 |
| MAPK3 | phosphorylation down-regulates | CASP8 | SIGNOR-203480 |
| MAPK14 | phosphorylation down-regulates | CASP8 | SIGNOR-122103 |