Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CDK1	CASP8	Ser387	YLEMDLSsPQTRYIP	phosphorylation down-regulates	20937773	SIGNOR-168446
PTPN6	CASP8	Tyr380	TDSEEQPyLEMDLSS	dephosphorylation up-regulates activity	18086677	SIGNOR-248477
PTPN6	CASP8	Tyr448	TILTEVNyEVSNKDD	dephosphorylation up-regulates activity	18086677	SIGNOR-248478
PLK3	CASP8	Thr273	DAGALTTtFEELHFE	phosphorylation up-regulates activity	27325299	SIGNOR-272995
MAPK3	CASP8	Ser387	YLEMDLSsPQTRYIP	phosphorylation down-regulates	24342355	SIGNOR-203480
LYN	CASP8	Tyr380	TDSEEQPyLEMDLSS	phosphorylation down-regulates activity	18086677	SIGNOR-272979
LYN	CASP8	Tyr448	TILTEVNyEVSNKDD	phosphorylation down-regulates activity	18086677	SIGNOR-272980
MAPK1	CASP8	Ser387	YLEMDLSsPQTRYIP	phosphorylation down-regulates	24342355	SIGNOR-203473
MAPK14	CASP8	Ser347	FTGLKCPsLAGKPKV	phosphorylation down-regulates	14970175	SIGNOR-122103
PLK1	CASP8	Ser305	IYQLMDHsNMDCFIC	phosphorylation down-regulates quantity by destabilization	24484936	SIGNOR-272989
Gbeta	CASP8	–		phosphorylation down-regulates	24342355	SIGNOR-270118
SRC	CASP8	Tyr380	TDSEEQPyLEMDLSS	phosphorylation down-regulates	16619028	SIGNOR-146127
ERK1/2	CASP8	Ser387	YLEMDLSsPQTRYIP	phosphorylation down-regulates	24342355	SIGNOR-244509
CyclinB/CDK1	CASP8	Ser387	YLEMDLSsPQTRYIP	phosphorylation down-regulates	20937773	SIGNOR-216737
RPS6KA3	CASP8	Thr263	SIRDRNGtHLDAGAL	phosphorylation down-regulates quantity by destabilization	21183680	SIGNOR-272997

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CDK1	phosphorylation up-regulates →	CASP8 PSer387	phosphorylation down-regulates ⊣	CASP8	20937773	SIGNOR-168446
PTPN6	dephosphorylation down-regulates ⊣	CASP8 PTyr380	dephosphorylation down-regulates ⊣	CASP8	18086677	SIGNOR-248477
PTPN6	dephosphorylation down-regulates ⊣	CASP8 PTyr448	dephosphorylation down-regulates ⊣	CASP8	18086677	SIGNOR-248478
PLK3	phosphorylation up-regulates →	CASP8 PThr273	phosphorylation up-regulates →	CASP8	27325299	SIGNOR-272995
MAPK3	phosphorylation up-regulates →	CASP8 PSer387	phosphorylation down-regulates ⊣	CASP8	24342355	SIGNOR-203480
LYN	phosphorylation up-regulates →	CASP8 PTyr380	phosphorylation down-regulates ⊣	CASP8	18086677	SIGNOR-272979
LYN	phosphorylation up-regulates →	CASP8 PTyr448	phosphorylation down-regulates ⊣	CASP8	18086677	SIGNOR-272980
MAPK1	phosphorylation up-regulates →	CASP8 PSer387	phosphorylation down-regulates ⊣	CASP8	24342355	SIGNOR-203473
MAPK14	phosphorylation up-regulates →	CASP8 PSer347	phosphorylation down-regulates ⊣	CASP8	14970175	SIGNOR-122103
PLK1	phosphorylation up-regulates →	CASP8 PSer305	phosphorylation down-regulates ⊣	CASP8	24484936	SIGNOR-272989
SRC	phosphorylation up-regulates →	CASP8 PTyr380	phosphorylation down-regulates ⊣	CASP8	16619028	SIGNOR-146127
ERK1/2	phosphorylation up-regulates →	CASP8 PSer387	phosphorylation down-regulates ⊣	CASP8	24342355	SIGNOR-244509
CyclinB/CDK1	phosphorylation up-regulates →	CASP8 PSer387	phosphorylation down-regulates ⊣	CASP8	20937773	SIGNOR-216737
RPS6KA3	phosphorylation up-regulates →	CASP8 PThr263	phosphorylation down-regulates ⊣	CASP8	21183680	SIGNOR-272997

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CDK1	phosphorylation down-regulates	CASP8	SIGNOR-168446
PTPN6	dephosphorylation → up-regulates activity	CASP8	SIGNOR-248477
PTPN6	dephosphorylation → up-regulates activity	CASP8	SIGNOR-248478
PLK3	phosphorylation → up-regulates activity	CASP8	SIGNOR-272995
MAPK3	phosphorylation down-regulates	CASP8	SIGNOR-203480
LYN	phosphorylation → down-regulates activity	CASP8	SIGNOR-272979
LYN	phosphorylation → down-regulates activity	CASP8	SIGNOR-272980
MAPK1	phosphorylation down-regulates	CASP8	SIGNOR-203473
MAPK14	phosphorylation down-regulates	CASP8	SIGNOR-122103
PLK1	phosphorylation down-regulates quantity by destabilization	CASP8	SIGNOR-272989
Gbeta	phosphorylation down-regulates	CASP8	SIGNOR-270118
SRC	phosphorylation down-regulates	CASP8	SIGNOR-146127
ERK1/2	phosphorylation down-regulates	CASP8	SIGNOR-244509
CyclinB/CDK1	phosphorylation down-regulates	CASP8	SIGNOR-216737
RPS6KA3	phosphorylation down-regulates quantity by destabilization	CASP8	SIGNOR-272997